RT Journal Article SR Electronic(1) A1 Horsnell, Christine A1 Gama, Rafael E. A1 Hughes, Pamela J. A1 Stanway, GlynYR 1995 T1 Molecular relationships between 21 human rhinovirus serotypes JF Journal of General Virology, VO 76 IS 10 SP 2549 OP 2555 DO https://doi.org/10.1099/0022-1317-76-10-2549 PB Microbiology Society, SN 1465-2099, AB We have analysed, by PCR using consensus primers followed by sequencing, 12 human rhinoviruses (HRVs) in a genomic region including that corresponding to the immunogenic site NIm-II. Together with published information, 21 sequences are available for comparison. In the region analysed, which encodes 112 amino acids, the majority (18) of the serotypes exhibited at least 70% amino acid identity to one another and some serotypes are very closely related. These include HRV-36, -58 and -89, known to exhibit antigenic cross-reactivity, which were shown to differ at only three amino acid positions. Three serotypes, HRV-3, -14 and -72, share at least 84% identity with one another but are less than 66% identical to the majority group. Interestingly, membership of these two molecular clusters correlates with the groupings determined by sensitivity to antivirus drugs, suggesting that they reflect a fundamental division of HRVs. In contrast, there is no correlation with receptor grouping, since the majority group contains members belonging to both HRV receptor groups., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-76-10-2549