f Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses
- Authors: G. Wutz, H. Auer†, N. Nowotny, B. Grosse, T. Skern, E. Kuechler
- J. Gen. Virol., August 1996 77: 1719-1730, doi: 10.1099/0022-1317-77-8-1719
- Subject: Animal - RNA viruses
- Published Online:
Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV.
Present address: Department of Occupational Medicine, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
© Society for General Microbiology Ltd 1996 | Published by the Microbiology Society
Full text loading...
Author and Article Information
/content/journal/jgv/10.1099/0022-1317-77-8-1719dcterms_title,dcterms_subject,pub_serialTitlepub_serialIdent:journal/jgv AND -contentType:BlogPost64
/content/journal/jgv/10.1099/0022-1317-77-8-1719dcterms_title,dcterms_subject-pub_serialIdent:journal/jgv AND -contentType:BlogPost64
Figure data loading....