RT Journal Article SR Electronic(1) A1 Wutz, G. A1 Auer, H. A1 Nowotny, N. A1 Grosse, B. A1 Skern, T. A1 Kuechler, E.YR 1996 T1 Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses JF Journal of General Virology, VO 77 IS 8 SP 1719 OP 1730 DO https://doi.org/10.1099/0022-1317-77-8-1719 PB Microbiology Society, SN 1465-2099, AB Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-8-1719