Human Cytomegalovirus Inhibits Peptide Translocation into the Endoplasmic Reticulum for MHC Class I Assembly

References

1. Androlewicz M. J., Anderson K. S., Cresswell P. 1993; Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proceedings of the National Academy of Sciences, USA 90:9130–9134
   [Google Scholar]
2. Baas E. J., van Santen H.-M., Kleijmeer M. J., Geuze H. J., Peters P. J., Ploegh H. L. 1992; Peptide-induced stabilization and intracellular localization of empty HLA class I complexes. Journal of Experimental Medicine 176:147–156
   [Google Scholar]
3. Barnes P. D., Grundy J. E. 1992; Down-regulation of the class I HLA heterodimer and β ₂-microglobulin on the surface of cells infected with cytomegalovirus. Journal of General Virology 73:2395–2403
   [Google Scholar]
4. Beersma M. F. C., Bijlmakers M. J. E., Ploegh H. L. 1993; Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. Journal of Immunology 151:4455–4464
   [Google Scholar]
5. Bluestone J. A., Jameson S., Miller S., Dick R. 1992; Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition. Journal of Experimental Medicine 176:1757–1761
   [Google Scholar]
6. Browne H., Smith G., Beck S., Minson T. 1990; A complex between the MHC class I homologue encoded by human cytomegalovirus and β₂ microglobulin. Nature 347:770–772
   [Google Scholar]
7. Burgert H. G., Kvist S. 1985; An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class 1 antigens. Cell 41:987–997
   [Google Scholar]
8. Cerundolo V., Alexander J., Anderson K., Lamb C., Cresswell P., McMichael A., Gotch F., Townsend A. 1990; Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature 345:449–452
   [Google Scholar]
9. Chee M. S., Bankier A. T., Beck S., Bohni R., Brown C. M., Cerny R., Horsnell T., Hutchison C. A. III, Kouzarides T., Martignetti J. A., Preddie E., Satchwell S. C., Tomlinson P., Weston K. M., Barrell B. G. 1990; Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Current Topics in Microbiology and Immunology 54:125–169
   [Google Scholar]
10. Degen E., Williams D. B. 1991; Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules. Journal of Cell Biology 112:1099–1115
    [Google Scholar]
11. Del Val M., Münch K., Reddehase M. J., Koszinowski U. H. 1989; Presentation of cytomegalovirus immediate-early antigens to cytolytic T lymphocytes is selectively blocked by viral genes expressed in the early phase. Cell 58:305–315
    [Google Scholar]
12. Del Val M., Hengel H., Häcker H., Hartlaub U., Ruppert T., Lucin P., Koszinowski U. H. 1992; Cytomegalovirus prevents antigen presentation blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. Journal of Experimental Medicine 172:729–738
    [Google Scholar]
13. Driscoll J., Finley D. 1992; A controlled breakdown: antigen processing and the turnover of viral proteins. Cell 68:823–825
    [Google Scholar]
14. Früh K., Ahn K., Djaballah H., Sempe P., van Endert P. M., Tampe R., Peterson P. A., Yang Y. 1995; A viral inhibitor of peptide transporters for antigen presentation. Nature 375:415–418
    [Google Scholar]
15. Gompels U. A., Nicholas J., Lawrence G., Jones M., Thompson B. J., Martin M. E. D., Efstathiou S., Craxton M., Macaulay H. A. 1995; The DNA sequence of human herpesvirus 6: structure, coding content and genome evolution. Virology 209:29–51
    [Google Scholar]
16. Grandea A. G., Androlewicz M. J., Athwal R. S., Geraghty D. E., Spies T. 1995; Dependence of peptide binding by MHC class I molecules on their interaction with TAP. Science 270:105–108
    [Google Scholar]
17. Hengel H., Lucin P., Jonjic S., Ruppert T., Koszinowski U. H. 1994; Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. Journal of Virology 68:289–297
    [Google Scholar]
18. Hengel H., EBIinger C., Pool J., Goulmy E., Koszinowski U. H. 1995; Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. Journal of General Virology 76:2987–2997
    [Google Scholar]
19. Hill A., Ploegh H. 1995; Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen. Proceedings of the National Academy of Sciences, USA 92:341–343
    [Google Scholar]
20. Hill A., Jugovic P., York I., Russ G., Bennink J., Yewdell J., Ploegh H., Johnson D. 1995; Herpes simplex virus turns off the TAP to evade host immunity. Nature 375:411–415
    [Google Scholar]
21. Ho M. 1982; Human cytomegalovirus infections in immunosuppressed patients. In Cytomegalovirus Biology and Infection: Current Topics in Infectious Disease pp 171–204 Edited by Greenough W. B., Merrigan T. C. New York: Plenum Press;
    [Google Scholar]
22. Jones T. R., Muzithras V. P. 1992; A cluster of dispensable genes within the human cytomegalovirus genome short component: IRS1, US1 through US5, and the US6 family. Journal of Virology 66:2541–2546
    [Google Scholar]
23. Jones T. R., Hanson L. K., Sun L., Slater J. S., Stenberg R. S., Campbell A. E. 1995; Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. Journal of Virology 69:4830–4841
    [Google Scholar]
24. Kelly A., Powis S. H., Kerr L.-A., Mockridge I., Elliot T., Bastin J., Uchanska-Ziegler B., Ziegler A., Trowsdale J., Townsend A. 1992; Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature 553:641–644
    [Google Scholar]
25. Kleijmeer M. J., Kelly A., Geuze H. J., Slot J. W., Townsend A., Trowsdale T. 1992; Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi. Nature 357:342–344
    [Google Scholar]
26. Kollert-Jöns A., Bogner E., Radsak K. 1991; A 15-kilobase-pair region of the human cytomegalovirus genome which includes US1 through US13 is dispensable for growth in cell culture. Journal of Virology 65:5184–5189
    [Google Scholar]
27. Krangel M. S., Orr H. T., Strominger J. L. 1979; Assembly and maturation of HLA-A and HLA-B antigens in vivo . Cell 18:979–991
    [Google Scholar]
28. Ljunggren H.-G., Stam N. S., Öhlen C., Neefjes J. J., Höglund P., Heemels M. T., Bastin J., Schumacher T. N. N., Townsend A., Kärre K., Ploegh H. L. 1990; Empty MHC class I molecules come out in the cold. Nature 346:476–480
    [Google Scholar]
29. Mockenhaupt T., Reschke M., Bogner E., Reis B., Radsak K. 1994; Structural analysis of the US-segment of a viable temperature sensitive human cytomegalovirus mutant. Archives of Virology 137:161–169
    [Google Scholar]
30. Momburg F., Roelse J., Hämmerling G. J., Neefjes J. J. 1994a; Peptide size selection by the major histocompatibility complex-encoded peptide transporter. Journal of Experimental Medicine 179:1613–1623
    [Google Scholar]
31. Momburg F. M., Roelse J., Howard J. C., Butcher G. W., Hämmerling G. J., Neefjes J. J. 1994b; Selectivity of MHC-encoded peptide transporters from human, mouse, and rat. Nature 367:648–651
    [Google Scholar]
32. Neefjes J. J., Hämmerling G. J., Momburg F. 1993a; Folding and assembly of major histocompatibility complex class 1 heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide. Journal of Experimental Medicine 178:1971–1980
    [Google Scholar]
33. Neefjes J. J., Momburg F., Hämmerling G. J. 1993b; Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261:769–771
    [Google Scholar]
34. Nijenhuis M., Schmitt S., Armandola E. A., Obst R., Brunner J., Hämmerling G. J. 1996; Identification of a contact region for peptide on the TAPI chain of transporter associated with antigen presentation. Journal of Immunology 156:2186–2195
    [Google Scholar]
35. Nößner E., Parham P. 1995; Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules. Journal of Experimental Medicine 181:327–337
    [Google Scholar]
36. Nuchtern J. G., Bonifacino J. S., Biddison W. E., Klausner R. D. 1989; Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature 339:223–226
    [Google Scholar]
37. Ortmann B., Androlewicz M. J., Cresswell P. 1994; MHC class I/β ₂-microglobulin complexes associate with TAP transporters before peptide binding. Nature 368:864–867
    [Google Scholar]
38. Reddehase M. J., Mutter W., Munch K., Bühring H.-J., Koszinowski U. H. 1987; CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. Journal of Virology 61:3102–3108
    [Google Scholar]
39. Riddell S., Watanabe K., Goodrich J., Li C. R., Agha M., Greenberg P. 1992; Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238–241
    [Google Scholar]
40. Rotem-Yehudar R., Winograd S., Sela S., Coligan J. E., Erlich R. 1994; Downregulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12. Journal of Experimental Medicine 180:477–488
    [Google Scholar]
41. Shepard J. C., Schumacher T. N. M., Ashton-Rickard P. G., Imaeda S., Ploegh H. L., Janeway C. A., Tonegawa S. 1993; TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74:577–584
    [Google Scholar]
42. Spies T., Cerundolo V., Colonna M., Cresswell P., Townsend A., DeMars R. 1992; Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature 355:644–646
    [Google Scholar]
43. Suh W.-K., Cohen-Doyle M. F., Früh K., Wang K., Peterson P. A., Williams D. B. 1994; Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264:1322–1326
    [Google Scholar]
44. Thäle R., Szepan U., Hengel H., Geginat G., Lucin P., Koszinowski U. H. 1995; Identification of the mouse cytomegalovirus genomic region affecting MHC class I molecule transport. Journal of Virology 69:6098–6105
    [Google Scholar]
45. Townsend A., Bodmer H. 1989; Antigen recognition by class I-restricted T lymphocytes. Annual Review of Immunology 7:601–624
    [Google Scholar]
46. Townsend A., Ohlen C., Bastin J., Ljunggren H.-G., Foster L., Kärre K. 1989; Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340:443–448
    [Google Scholar]
47. Warren A. P., Ducroq D. H., Lehner P. J., Borysiewicz L. K. 1994; Human-cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes. Journal of Virology 68:2822–2829
    [Google Scholar]
48. Wiertz E. J. H. J., Jones T. R., Sun L., Bogyo M., Geuze H. J., Ploegh H. L. 1996; The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84:769–779
    [Google Scholar]
49. Yamanishi F., Rapp F. 1979; Induction of host DNA synthesis and DNA polymerase by DNA-negative temperature-sensitive mutants of human cytomegalovirus. Virology 94:237–241
    [Google Scholar]
50. Yamashita Y., Shimokata K., Mizuno S., Yamaguchi H., Nishiyama Y. 1993; Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus. Virology 193:727–736
    [Google Scholar]
51. York I. A., Roop C., Andrews D. W., Riddell S. R., Graham F. L., Johnson D. C. 1994; A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8⁺ T lymphocytes. Cell 77:525–535
    [Google Scholar]