1887

Abstract

The finding that a senescence-accelerated mouse (SAMP8) shows early brain ageing, with histopathological changes resembling those seen in scrapie, combined with the discovery of high levels of endogenous murine leukaemia virus (MuLV) in brains of SAMP8 mice prompted us to examine the effect of scrapie infection on MuLV titres in this strain and in one of its progenitors, the AKR strain. Three scrapie strains (ME7, 22L and 139A) that had a comparatively short incubation period in SAMP8 and AKR mice caused an increase in brain MuLV titres that was scrapie strain-specific: in each mouse strain, the greatest effect was with 1 39A, and the least with ME7. The 22A scrapie strain, which has a long incubation period in SAMP8 mice, did not affect MuLV titres in brains of this mouse strain. Previous analyses of scrapie incubation periods in AKR, SAMP8 and another strain derived from an AKR cross (SAMR1) showed an inverse relationship between brain MuLV titres and scrapie incubation periods. This finding, combined with the effect of scrapie on MuLV titres, suggests an interaction between the scrapie infectious process and MuLV replication.

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1999-01-01
2024-04-19
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References

  1. Akiguchi I., Yagi H., Ueno M., Takemura M., Kitabayashi T., Seriu N., Kawamata T., Nakamura S., Shimada A., Takeda T. 1994; Age related morphological changes in the brain of senescence-accelerated mouse (SAMP8). In The SAM Model of Senescence Proceedings of the First International Conference on Senescence pp 67–72 Edited by Takeda T. Amsterdam: Elsevier;
    [Google Scholar]
  2. Akowitz A., Sklaviadis T., Manuelidis L. 1994; Endogenous viral complexes with long RNA cosediment with the agent of Creutzfeldt–Jakob Disease. Nucleic Acids Research 22:1101–1107
    [Google Scholar]
  3. Bruce M. E., Dickinson A. G., Fraser H. 1976; Cerebral amyloidosis in scrapie in the mouse, effect of agent strain and mouse genotype. Neuropathology and Applied Neurobiology 2:471–478
    [Google Scholar]
  4. Carlson G. A., Kingsbury D. T., Goodman P. A., Coleman S., Marshall S. T., DeArmond S. J., Westway D., Prusiner S. B. 1986; Prion protein and scrapie incubation time genes are linked. Cell 46:503–511
    [Google Scholar]
  5. Carp R. I., Callahan S. M. 1986; Scrapie incubation periods and end-point titers in mouse strains differing at the H-2D locus. Intervirology 26:85–92
    [Google Scholar]
  6. Carp R. I., Callahan S. M. 1991; Variation in the characteristics of 10 mouse-passaged scrapie lines derived from five scrapie-positive sheep. Journal of General Virology 72:293–298
    [Google Scholar]
  7. Carp R. I., Rubenstein R. 1991; Diversity and significance of scrapie strains. Seminars in Virology 2:203–213
    [Google Scholar]
  8. Carp R. I., Callahan S. M., Sersen E. A., Moretz R. C. 1984; Preclinical changes in weight of scrapie-infected mice as a function of scrapie agent–mouse strain combination. Intervirology 21:61–69
    [Google Scholar]
  9. Carp R. I., Merz P. A., Moretz R. C., Somerville R. A., Callahan S. M., Wisniewski H. M. 1985; Biological properties of scrapie: an unconventional slow virus. In Subviral Pathogens of Plants and Animals Viroids and Prions pp 425–463 Edited by Maramorosch K. McKelvey J. J. Jr New York: Academic Press;
    [Google Scholar]
  10. Carp R. I., Kim Y. S., Callahan S. M. 1989; Scrapie-induced alterations in glucose tolerance in mice. Journal of General Virology 70:827–835
    [Google Scholar]
  11. Carp R. I., Meeker H., Sersen E., Kozlowski P. 1998; Analysis of the incubation periods, induction of obesity and histopathological changes in senescence-prone and senescence-resistant mice infected with various scrapie strains. Journal of General Virology 79:2863–2869
    [Google Scholar]
  12. Dickinson A. G., Fraser H. 1979; An assessment of the genetics of scrapie in sheep and mice. In Slow Transmissible Diseases of the Nervous System vol 1 pp 367–385 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  13. Dickinson A. G., Meikle V. M. H. 1971; Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular General Genetics 112:73–79
    [Google Scholar]
  14. Dickinson A. G., Outram G. W. 1986; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis. In Novel Infectious Agents and the Central Nervous System pp 63–83 Edited by Bock G., Marsh J. Chichester: Wiley;
    [Google Scholar]
  15. Dickinson A. G., Meikle V. M. H., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79:15–22
    [Google Scholar]
  16. Eklund C. M., Hadlow W. J., Kennedy R. C. 1965; Some properties of the scrapie agent and its behavior in mice. Proceedings of the Society for Experimental Biology and Medicine 112:974–979
    [Google Scholar]
  17. Field E. J., Peat A. 1969; Structural changes in scrapie-affected brain. Biochemical Journal19P–20P
    [Google Scholar]
  18. Flood J. F., Morley J. E. 1992; Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. Journal of Geronotology 47:B52–B59
    [Google Scholar]
  19. Flood J. F., Morley J. E. 1998; Learning and memory in the SAMP8 mouse. Neuroscience and Biobehavioral Reviews 22:1–20
    [Google Scholar]
  20. Flood J. F., Morely P. M. K., Morley J. E. 1995; Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes. Physiology Behavior 58:819–822
    [Google Scholar]
  21. Fraser H. 1979; Neuropathology of scrapie: the precision of the lesions and their diversity. In Slow Transmissible Diseases of the Nervous System vol 1 pp 387–406 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  22. Gravel C., Kay D. D., Jolicoeur P. 1993; Identification of the infected target cell type in spongiform myeloencephalopathy induced by the neurotropic Cas-Br-E murine leukemia virus. Journal of Virology 67:6648–6658
    [Google Scholar]
  23. Hosokawa M. 1994; Grading score system; a method of evaluation of the degree of senescence in senescence-accelerated mouse (SAM). In The SAM Model of Senescence pp 23–28 Edited by Takeda T. Amsterdam: Elsevier Science;
    [Google Scholar]
  24. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1987; Scrapie-induced obesity in mice. Journal of Infectious Diseases 156:402–405
    [Google Scholar]
  25. Kingsbury D. T., Kasper K. C., Stites D. P., Watson J. D., Hogan R. N., Prusiner S. B. 1983; Genetic control of scrapie and Creutzfeldt–Jakob disease in mice. Immunology 131:491–496
    [Google Scholar]
  26. Kitado H., Higuchi K., Takeda T. 1994; Molecular genetic characterization of the senescence-accelerated mouse (SAM) strains. Journal of Gerontology 49:B247–B254
    [Google Scholar]
  27. Lynch W. P., Snyder E. Y., Qualtiere L., Portis J. L., Sharpe A. H. 1996; Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brain. Journal of Virology 70:8896–8907
    [Google Scholar]
  28. Manuelidis E. E., Kim J. H., Manuelidis L. 1983; Novel biological properties of Creutzfeldt–Jakob infected strains in vitro. In Biological Aspects of Alzheimer s Disease, Banbury Report 15 pp 413–422 Edited by Katzman R. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
  29. Manuelidis E. E., Fritch W. W., Kim J. H., Manuelidis L. 1987; Immortality of cell cultures derived from brains of mice and hamsters infected with Creutzfeldt–Jakob disease. Proceedings of the National Academy of Sciences, USA 84:871–875
    [Google Scholar]
  30. Meeker H. C., Carp R. I. 1997; Titers of murine leukemia virus are higher in brains of SAMP8 than SAMR1 mice. Neurobiology of Ageing 18:543–547
    [Google Scholar]
  31. Miyamoto M., Kiyota Y., Yamazaki N., Nagaoka A., Matsuo T., Nagawa Y., Takeda T. 1986; Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiology & Behavior 38:399–406
    [Google Scholar]
  32. Mohri S., Tateishi J. 1989; Host genetic control of incubation periods of Creutzfeldt–Jakob Disease in mice. Journal of General Virology 70:1391–1400
    [Google Scholar]
  33. Murdoch G. H., Sklaviadis T., Manuelidis E. E., Manuelidis L. 1990; Potential retroviral RNAs in Creutzfeldt–Jakob Disease. Journal of Virology 64:1477–1486
    [Google Scholar]
  34. Oldstone M. B. A., Aoki T., Dixon F. J. 1971; Activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus. Science 174:843–845
    [Google Scholar]
  35. Oleszak E. L., Manuelidis L., Manuelidis E. E. 1986; In vitro transformation elicited by Creutzfeldt–Jakob infected brain material. Journal of Neuropathology and Experimental Neurology 45:489–502
    [Google Scholar]
  36. Pease L. R., Murphy W. H. 1980; Co-infection by lactic dehydrogenase virus and C-type retrovirus elicits neurological disease. Nature 286:398–400
    [Google Scholar]
  37. Pease L. R., Abrams G. D., Murphy W. H. 1982; FV-1 restriction of age-dependent paralytic lactic dehydrogenase virus infection. Virology 117:29–37
    [Google Scholar]
  38. Risser R., Horowitz J. M. 1983; Endogenous mouse leukemia viruses. Annual Review of Genetics 17:85–121
    [Google Scholar]
  39. Rowe W. P. 1975-1976; Leukemia virus genomes in the chromosomal DNA of the mouse. Harvey Lectures 71:173–192
    [Google Scholar]
  40. Takeda T., Hosokawa M., Higuchi K. 1994; Senescence accelerated mouse (SAM). A novel murine model of ageing. In The SAM Model of Senescence, Proceedings of the First International Conference on Senescence pp 15–22 Edited by Takeda T. Amsterdam: Elsevier;
    [Google Scholar]
  41. Takeda T., Hosokawa M., Higuchi K. 1997; Senescence-accelerated mouse (SAM): a novel murine model of senescence. Experimental Gerontology 32:105–109
    [Google Scholar]
  42. Temin H. M. 1992; Origin and general nature of retroviruses. In The Retroviridae pp 1–18 Edited by Levy J. A. New York: Plenum Press;
    [Google Scholar]
  43. Williams A. E., Lawson L., J Parry V. H., Fraser H. 1994; Characterization of the microglial response in murine scrapie. Neuropathology and Applied Neurobiology 20:47–55
    [Google Scholar]
  44. Williams A., Lucassen P. J., Ritchie D., Bruce M. 1997; PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Experimental Neurology 144:433–438
    [Google Scholar]
  45. Yagi H., Irino M., Matsushita T., Seika K., Umbezawa M., Tsuboyama T., Hosokawa M., Akiguchi I., Tokunaga R., Takeda T. 1989; Spontaneous spongy degeneration of the brain stem in SAM-P/8 mice, a newly developed memory deficient strain. Journal of Neuropathology and Experimental Neurology 48577–590
    [Google Scholar]
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