1887

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Volume 80, Issue 2

Activation of retroperitoneal fibromatosis-associated herpesvirus, a simian homologue of human herpesvirus-8 Free

Abstract

Retroperitoneal fibromatosis-associated herpesvirus of rhesus macaques (RFHVMm) is a gammaherpesvirus closely related to human herpesvirus-8 (HHV-8), which is thought to be a necessary cofactor for the development of Kaposi’s sarcoma (KS) in humans. Here, RFHVMm infection of rhesus macaques exposed to the D-type retrovirus simian retrovirus-2 (SRV-2) is described. Development of SRV-2 viraemia, infection with simian immunodeficiency virus or administration of cyclosporin A could result in persistent RFHVMm viraemia. From this, it is concluded that productive retrovirus infection or otherwise-induced immune suppression has the ability to activate this herpesvirus in vivo. Elevated levels of circulating interleukin-6, a cytokine that plays a central role in KS, were found in RFHVMm-viraemic animals. In viraemic animals, RFHVMm was found in tissues that are common sites for the development of AIDS-associated KS, especially the oral cavity. Together, these data suggest a common biology between RFHVMm infection of macaques and HHV-8 infection and pathogenesis in humans.

  • Received:
  • Accepted:
  • Published Online:
© Journal of General Virology 1999
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1999-02-01
2024-04-18
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Activation in vivo of retroperitoneal fibromatosis-associated herpesvirus, a simian homologue of human herpesvirus-8
J. Gen. Virol. 80, 467 (1999); https://doi.org/10.1099/0022-1317-80-2-467
/content/journal/jgv/10.1099/0022-1317-80-2-467
/content/journal/jgv/10.1099/0022-1317-80-2-467
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