1887

Abstract

We have demonstrated previously that the envelope proteins of a murine retrovirus (Moloney murine leukaemia virus) and a simian retrovirus (Mason–Pfizer monkey virus) have immunosuppressive properties . This property was manifested by the ability of the proteins, when expressed by tumour cells normally rejected by engrafted mice, to allow the envelope-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of infectious retroviruses, but is also shared by the envelope protein encoded by an endogenous retrovirus of humans belonging to the HERV-H family. These results emphasize the close relationship between endogenous and infectious retroviruses and might be important in relation to the process of tumour progression in humans.

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2001-10-01
2024-04-16
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References

  1. Blaise S., Mangeney M., Heidmann T. 2001; The envelope of Mason–Pfizer monkey virus has immunosuppressive properties. Journal of General Virology 82:1597–1600
    [Google Scholar]
  2. Cianciolo G. J., Copeland T. D., Oroszlan S., Snyderman R. 1985; Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 230:453–455
    [Google Scholar]
  3. de Parseval N., Heidmann T. 1998; Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population. Journal of Virology 72:3442–3445
    [Google Scholar]
  4. de Parseval N., Casella J., Gressin L., Heidmann T. 2001; Characterization of the three HERV-H proviruses with an open envelope reading frame encompassing the immunosuppressive domain and evolutionary history in primates. Virology 279:558–569
    [Google Scholar]
  5. Lindeskog M., Mager D. L., Blomberg J. 1999; Isolation of a human endogenous retroviral HERV-H element with an open env reading frame. Virology 258:441–450
    [Google Scholar]
  6. Löwer R., Löwer J., Kurth R. 1996; The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences. Proceedings of the National Academy of Sciences, USA 93:5177–5184
    [Google Scholar]
  7. Mangeney M., Heidmann T. 1998; Tumor cells expressing a retroviral envelope escape immune rejection in vivo. Proceedings of the National Academy of Sciences, USA 95:14920–14925
    [Google Scholar]
  8. Tanaka K., Gorelik E., Watanabe M., Hozumi N., Jay G. 1988; Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene. Molecular and Cellular Biology 8:1857–1861
    [Google Scholar]
  9. Tönjes R. R., Czauderna F., Kurth R. 1999; Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. Journal of Virology 73:9187–9195
    [Google Scholar]
  10. Urnovitz H. B., Murphy W. H. 1996; Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease. Clinical Microbiology Reviews 9:72–99
    [Google Scholar]
  11. Voisset C., Bouton O., Bedin F., Duret L., Mandrand B., Mallet F., Paranhos-Baccalà G. 2000; Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family . AIDS. Research and Human Retroviruses 16:731–740
    [Google Scholar]
  12. Wilkinson D. A., Mager D. L., Leong J. A. C. 1994; Endogenous human retroviruses. In The Retroviridae pp 465–535 Edited by Levy J. A. New York: Plenum;
    [Google Scholar]
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