1887

Abstract

Our previous work has shown that high avidity cytotoxic T lymphocytes (CTL) are optimal for virus clearance and thus it is necessary that an effective vaccine is capable of eliciting high avidity CTL. To determine if vaccination with the paramyxovirus simian virus 5 (SV5) elicits a high avidity response to a model foreign antigen, a recombinant virus was engineered to express chicken ovalbumin (rSV5–Ova). To compare the CTL response elicited with rSV5–Ova and a recombinant vaccinia virus expressing ovalbumin (rVV–Ova), mice were vaccinated intranasally with various doses of each vector and the Ova-specific CTL response was determined by ELISPOT analysis. Here, it has been shown that rSV5 can be equally as effective as rVV in eliciting antigen-specific CTL, in terms of both the total number of CTL and the number of high avidity cells. This has implications for both the design of vaccine vectors and the route utilized for vaccine administration for the elicitation of high avidity CTL responses. The advantages and future potential use of rSV5 vaccine vectors are discussed.

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2002-05-01
2024-03-28
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References

  1. Alexander M. A., Damico C. A., Wieties K. M., Hansen T. H., Connolly J. M. 1991; Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes. Journal of Experimental Medicine 173:849–858
    [Google Scholar]
  2. Alexander-Miller M. A. 2000; Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection. Cellular Immunology 201:58–62
    [Google Scholar]
  3. Alexander-Miller M. A., Leggatt G. R., Berzofsky J. A. 1996; Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proceedings of the National Academy of Sciences, USA 93:4102–4107
    [Google Scholar]
  4. Baty D. U., Southern J. A., Randall R. E. 1991; Sequence comparison between the haemagglutinin–neuraminidase genes of simian, canine and human isolates of simian virus 5. Journal of General Virology 72:3103–3107
    [Google Scholar]
  5. Berglund P., Quesada-Rolander M., Putkonen P., Biberfeld G., Thorstensson R., Liljestrom P. 1997; Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus. AIDS Research and Human Retroviruses 13:1487–1495
    [Google Scholar]
  6. Bilyk N., Holt P. G. 1993; Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. Journal of Experimental Medicine 177:1773–1777
    [Google Scholar]
  7. Cairns J. S., Sarver N. 1998; New viral vectors for HIV vaccine delivery. AIDS Research and Human Retroviruses 14:1501–1508
    [Google Scholar]
  8. Caley I. J., Betts M. R., Irlbeck D. M., Davis N. L., Swanstrom R., Frelinger J. A., Johnston R. E. 1997; Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. Journal of Virology 71:3031–3038
    [Google Scholar]
  9. Cohn M. L., Robinson E. D., Thomas D., Faerber M., Carey S., Sawyer R., Goswami K. K., Johnson A. H., Richert J. R. 1996; T cell responses to the paramyxovirus simian virus 5: studies in multiple sclerosis and normal populations. Pathobiology 64:131–135
    [Google Scholar]
  10. Constant S. L., Lee K. S., Bottomly K. 2000; Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. European Journal of Immunology 30:840–847
    [Google Scholar]
  11. Conzelmann K. K. 1996; Genetic manipulation of non-segmented negative-strand RNA viruses. Journal of General Virology 77:381–389
    [Google Scholar]
  12. Craiu A., Akopian T., Goldberg A., Rock K. L. 1997; Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide. Proceedings of the National Academy of Sciences, USA 94:10850–10855
    [Google Scholar]
  13. Derby M., Alexander-Miller M., Tse R., Berzofsky J. 2001; High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL. Journal of Immunology 166:1690–1697
    [Google Scholar]
  14. Erickson A. H., Blobel G. 1979; Early events in the biosynthesis of the lysosomal enzyme cathepsin D. Journal of Biological Chemistry 254:11771–11774
    [Google Scholar]
  15. Gallimore A., Dumrese T., Hengartner H., Zinkernagel R. M., Rammensee H. G. 1998; Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. Journal of Experimental Medicine 187:1647–1657
    [Google Scholar]
  16. Goswami K. K., Lange L. S., Mitchell D. N., Cameron K. R., Russell W. C. 1984; Does simian virus 5 infect humans?. Journal of General Virology 65:1295–1303
    [Google Scholar]
  17. He B., Paterson R. G., Ward C. D., Lamb R. A. 1997; Recovery of infectious SV5 from cloned DNA and expression of a foreign gene. Virology 237:249–260
    [Google Scholar]
  18. Herscowitz H. B. 1985; In defense of the lung: paradoxical role of the pulmonary alveolar macrophage. Annals of Allergy 55:634–650
    [Google Scholar]
  19. Kieny M. P., Lathe R., Drillien R., Spehner D., Skory S., Schmitt D., Wiktor T., Koprowski H., Lecocq J. P. 1984; Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature 312:163–166
    [Google Scholar]
  20. Lamb R. A., Kolakofsky D. 1996; Paramyxoviridae: the viruses and their replication. In Fields Virology pp 1177–1204 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  21. McAllister A., Arbetman A. E., Mandl S., Pena-Rossi C., Andino R. 2000; Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases. Journal of Virology 74:9197–9205
    [Google Scholar]
  22. Mandl S., Sigal L. J., Rock K. L., Andino R. 1998; Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen. Proceedings of the National Academy of Sciences, USA 95:8216–8221
    [Google Scholar]
  23. Morrow C. D., Porter D. C., Ansardi D. C., Moldoveanu Z., Fultz P. N. 1994; New approaches for mucosal vaccines for AIDS: encapsidation and serial passages of poliovirus replicons that express HIV-1 proteins on infection. AIDS Research and Human Retroviruses 10 (Suppl. 2):S61–S66
    [Google Scholar]
  24. Muster T., Ferko B., Klima A., Purtscher M., Trkola A., Schulz P., Grassauer A., Engelhardt O. G., Garcìa-Sástre A., Palese P., Katinger H. 1995; Mucosal model of immunization against human immunodeficiency virus type 1 with a chimeric influenza virus. Journal of Virology 69:6678–6686
    [Google Scholar]
  25. Ng D. T., Randall R. E., Lamb R. A. 1989; Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin–neuraminidase: specific and transient association with GRP78–BiP in the endoplasmic reticulum and extensive internalization from the cell surface. Journal of Cell Biology 109:3273–3289
    [Google Scholar]
  26. Palese P. 1998; RNA virus vectors: where are we and where do we need to go?. Proceedings of the National Academy of Sciences, USA 95:12750–12752
    [Google Scholar]
  27. Parks G. D., Ward K. R., Rassa J. C. 2001; Increased readthrough transcription across the simian virus 5 M–F gene junction leads to growth defects and a global inhibition of viral mRNA synthesis. Journal of Virology 75:2213–2223
    [Google Scholar]
  28. Restifo N. P., Bacik I., Irvine K. R., Yewdell J. W., McCabe B. J., Anderson R. W., Eisenlohr L. C., Rosenberg S. A., Bennink J. R. 1995; Antigen processing in vivo and the elicitation of primary CTL responses. Journal of Immunology 154:4414–4422
    [Google Scholar]
  29. Roberts A., Buonocore L., Price R., Forman J., Rose J. K. 1999; Attenuated vesicular stomatitis viruses as vaccine vectors. Journal of Virology 73:3723–3732
    [Google Scholar]
  30. Schnell M. J., Foley H. D., Siler C. A., McGettigan J. P., Dietzschold B., Pomerantz R. J. 2000; Recombinant rabies virus as potential live-viral vaccines for HIV-1. Proceedings of the National Academy of Sciences, USA 97:3544–3549
    [Google Scholar]
  31. Stumbles P. A., Thomas J. A., Pimm C. L., Lee P. T., Venaille T. J., Proksch S., Holt P. G. 1998; Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. Journal of Experimental Medicine 188:2019–2031
    [Google Scholar]
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