%0 Journal Article %A Hoa, Le Nguyen Minh %A Tuan, Nguyen Anh %A My, Pham Ha %A Huong, Tran Thi Kieu %A Chi, Nguyen Thi Yen %A Hau Thu, Trang Thi %A Carrique-Mas, Juan %A Duong, Mai Thuy %A Tho, Nguyen Dang %A Hoang, Nguyen Dang %A Thanh, To Long %A Diep, Nguyen Thi %A Duong, Nguyen van %A Toan, Tran Khanh %A Tung, Trinh Son %A Mai, Le Quynh %A Iqbal, Munir %A Wertheim, Heiman %A van Doorn, H. Rogier %A Bryant, Juliet E. %A the VIZIONS consortium %T Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam %D 2017 %J Journal of General Virology, %V 98 %N 8 %P 2011-2016 %@ 1465-2099 %R https://doi.org/10.1099/jgv.0.000877 %K avian influenza %K H9N2 %K poultry %K seroepidemiology %K Vietnam %K zoonoses %I Microbiology Society, %X Rural farming communities in northern Vietnam do not routinely practice vaccination for influenza A viruses (IAV) for either humans or poultry, which enables us to study transmission intensity via seroepidemiology. Using samples from a longitudinal cohort of farming households, we determined the number of symptomatic and asymptomatic human infections for seasonal IAV and avian A/H9 over 2 years. As expected, we detected virologically confirmed acute cases of seasonal IAV in humans, as well as large numbers of subclinical seroconversions to A/H1pdm [55/265 (21 %)], A/H3 [95/265 (36 %)] and A/H9 [24/265 (9 %)]. Five of the A/H9 human seroconverters likely represented true infections rather than heterosubtypic immunity, because the individuals seroconverted solely to A/H9. Among co-located poultry, we found significantly higher seroprevalance for A/H5 compared to A/H9 in both chickens and ducks [for northern study sites overall, 337/1105 (30.5 %) seropositive for A/H5 and 123/1105 (11.1 %) seropositive for A/H9]. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000877