Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam
Hoa, Le Nguyen Minh and Tuan, Nguyen Anh and My, Pham Ha and Huong, Tran Thi Kieu and Chi, Nguyen Thi Yen and Hau Thu, Trang Thi and Carrique-Mas, Juan and Duong, Mai Thuy and Tho, Nguyen Dang and Hoang, Nguyen Dang and Thanh, To Long and Diep, Nguyen Thi and Duong, Nguyen van and Toan, Tran Khanh and Tung, Trinh Son and Mai, Le Quynh and Iqbal, Munir and Wertheim, Heiman and van Doorn, H. Rogier and Bryant, Juliet E. and the VIZIONS consortium,, 98, 2011-2016 (2017),
doi = https://doi.org/10.1099/jgv.0.000877,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Rural farming communities in northern Vietnam do not routinely practice vaccination for influenza A viruses (IAV) for either humans or poultry, which enables us to study transmission intensity via seroepidemiology. Using samples from a longitudinal cohort of farming households, we determined the number of symptomatic and asymptomatic human infections for seasonal IAV and avian A/H9 over 2 years. As expected, we detected virologically confirmed acute cases of seasonal IAV in humans, as well as large numbers of subclinical seroconversions to A/H1pdm [55/265 (21 %)], A/H3 [95/265 (36 %)] and A/H9 [24/265 (9 %)]. Five of the A/H9 human seroconverters likely represented true infections rather than heterosubtypic immunity, because the individuals seroconverted solely to A/H9. Among co-located poultry, we found significantly higher seroprevalance for A/H5 compared to A/H9 in both chickens and ducks [for northern study sites overall, 337/1105 (30.5 %) seropositive for A/H5 and 123/1105 (11.1 %) seropositive for A/H9].,
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