Chicken anaemia virus evades host immune responses in transformed lymphocytes
Giotis, Efstathios S. and Scott, Alistair and Rothwell, Lisa and Hu, Tuanjun and Talbot, Richard and Todd, Daniel and Burt, David W. and Glass, Elizabeth J. and Kaiser, Pete,, 99, 321-327 (2018),
doi = https://doi.org/10.1099/jgv.0.001011,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Chicken anaemia virus (CAV) is a lymphotropic virus that causes anaemia and immunosuppression in chickens. Previously, we proposed that CAV evades host antiviral responses in vivo by disrupting T-cell signalling, but the precise cellular targets and modes of action remain elusive. In this study, we examined gene expression in Marek’s disease virus-transformed chicken T-cell line MSB-1 after infection with CAV using both a custom 5K immune-focused microarray and quantitative real-time PCR at 24, 48 and 72 h post-infection. The data demonstrate an intricate equilibrium between CAV and the host gene expression, displaying subtle but significant modulation of transcripts involved in the T-cell, inflammation and NF-κB signalling cascades. CAV efficiently blocked the induction of type-I interferons and interferon-stimulated genes at 72 h. The cell expression pattern implies that CAV subverts host antiviral responses and that the transformed environment of MSB-1 cells offers an opportunistic advantage for virus growth.,
language=,
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