Two novel noroviruses and a novel norovirus genogroup in California sea lions
Teng, Jade L. L. and Martelli, Paolo and Chan, Wan-Mui and Lee, Hwei Huih and Hui, Suk-Wai and Lau, Candy C. Y. and Tse, Herman and Yuen, Kwok-Yung and Lau, Susanna K. P. and Woo, Patrick C. Y.,, 99, 777-782 (2018),
doi = https://doi.org/10.1099/jgv.0.001071,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= In this study, two novel noroviruses (NoVs) were discovered from faecal samples from California sea lions from an oceanarium in Hong Kong, and named California sea lion NoV 1 (Csl/NoV1) and California sea lion NoV 2 (Csl/NoV2). Whole-genome sequencing showed that the genome organization and amino acid motifs of both Csl/NoV1 and Csl/NoV2 were typical of those of other NoVs in their open reading frames (ORFs). Csl/NoV1 possessed only 52.6–52.8 % amino acid identity in VP1 to the closest matches in genogroup GII. Therefore, Csl/NoV1 should constitute a novel genogroup of NoV. Shifting of the phylogenetic position of Csl/NoV1 in the RdRp, VP1 and VP2 trees was observed, which may have been due to recombination events and/or biased mutations. Csl/NoV2 possessed 55.4–56.2 % amino acid identity in VP1 to its closest relatives in genogroup GVI, which means that it represents a new genotype in genogroup GVI. Further studies will reveal what diseases these NoVs can cause in marine mammals.,
language=,
type=