%0 Journal Article %A Delatorre, Edson %A Miranda, Milene %A Tschoeke, Diogo A. %A Carvalho de Sequeira, Patrícia %A Alves Sampaio, Simone %A Barbosa-Lima, Giselle %A Rangel Vieira, Yasmine %A Leomil, Luciana %A Bozza, Fernando A. %A Cerbino-Neto, José %A Bozza, Patricia T. %A Ribeiro Nogueira, Rita Maria %A Brasil, Patrícia %A Thompson, Fabiano L. %A de Filippis, Ana M. B. %A Souza, Thiago Moreno L. %T An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels %D 2018 %J Journal of General Virology, %V 99 %N 7 %P 913-916 %@ 1465-2099 %R https://doi.org/10.1099/jgv.0.001080 %K neurological disease %K zika %K Brazil %K neurotropism %K Zika virus %K Rio de Janeiro %I Microbiology Society, %X Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine). %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001080