RT Journal Article SR Electronic(1) A1 Delatorre, Edson A1 Miranda, Milene A1 Tschoeke, Diogo A. A1 Carvalho de Sequeira, Patrícia A1 Alves Sampaio, Simone A1 Barbosa-Lima, Giselle A1 Rangel Vieira, Yasmine A1 Leomil, Luciana A1 Bozza, Fernando A. A1 Cerbino-Neto, José A1 Bozza, Patricia T. A1 Ribeiro Nogueira, Rita Maria A1 Brasil, Patrícia A1 Thompson, Fabiano L. A1 de Filippis, Ana M. B. A1 Souza, Thiago Moreno L.YR 2018 T1 An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels JF Journal of General Virology, VO 99 IS 7 SP 913 OP 916 DO https://doi.org/10.1099/jgv.0.001080 PB Microbiology Society, SN 1465-2099, AB Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001080