1887

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Volume 90, Issue 1

Cytokine production by human herpesvirus 8-infected dendritic cells Free

Abstract

We have shown previously that human herpesvirus 8 (HHV-8)-infected dendritic cells (DCs) undergo incomplete maturation and have a defective antigen-presenting function. Here, we examined the effects of HHV-8 infection on cytokine production, which is critical to the function of DCs. We detected expression of interleukin (IL)-6, tumour necrosis factor (TNF)-, macrophage inflammatory protein (MIP)-1, MIP-1, RANTES and IL-12p40 from 2 to 6 h post-infection, and these peaked by 15–24 h. Expression of these factors decreased 24–48 h post-infection, with the exception of TNF- which remained high throughout the entire 72 h. Interestingly, while IL-12p40 expression increased post-infection, bioactive IL-12p70 was not detected in the supernatants. These results suggest an intentional skewing of cytokine production in HHV-8-infected DCs towards induction of a Th2 response.

  • Received:
  • Accepted:
  • Published Online:
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2009-01-01
2024-04-19
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Cytokine production by human herpesvirus 8-infected dendritic cells
J. Gen. Virol. 90, 79 (2009); https://doi.org/10.1099/vir.0.006239-0
/content/journal/jgv/10.1099/vir.0.006239-0
/content/journal/jgv/10.1099/vir.0.006239-0
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