@article{mbs:/content/journal/jgv/10.1099/vir.0.009308-0, author = "Miao, Congrong and Radu, Gertrud U. and Caidi, Hayat and Tripp, Ralph A. and Anderson, Larry J. and Haynes, Lia M.", title = "Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab′)2 components mediates reduced pulmonary inflammation in mice", journal= "Journal of General Virology", year = "2009", volume = "90", number = "5", pages = "1119-1123", doi = "https://doi.org/10.1099/vir.0.009308-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.009308-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Therapeutic treatment with a non-neutralizing monoclonal antibody (mAb) (131-2G) specific to respiratory syncytial virus (RSV) G glycoprotein mediates virus clearance and decreases leukocyte trafficking and interferon gamma (IFN-γ) production in the lungs of RSV-infected mice. Its F(ab′)2 component only mediates decreased leukocyte trafficking and IFN-γ production without reducing virus replication. Thus, this mAb has two independent actions that could facilitate treatment and/or prevention of RSV infection by reducing both virus replication and virus-induced pulmonary inflammation.", }