RT Journal Article SR Electronic(1) A1 Fan, JunYR 2009 T1 Open reading frame structure analysis as a novel genotyping tool for hepatitis E virus and the subsequent discovery of an inter-genotype recombinant JF Journal of General Virology, VO 90 IS 6 SP 1353 OP 1358 DO https://doi.org/10.1099/vir.0.009431-0 PB Microbiology Society, SN 1465-2099, AB Accurate viral genotyping is important. Here I investigate genotypes in hepatitis E virus (HEV) and find that the open reading frame (ORF) structure (the lengths of three ORFs and the overlapping relationships among the ORFs) can be a good criterion for genotyping HEV. An inter-genotype recombinant (GenBank accession no. DQ450072) was revealed by analysing the ORF structure and confirmed by phylogenetic analyses. This discovery of the inter-genotype recombinant indicates that genotyping in HEV should be based on full-length sequences. The Mexican strain which is currently classified as a genotype 2 strain also exhibited the mosaic sequence pattern, although without statistical support., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.009431-0