RT Journal Article SR Electronic(1) A1 Saunders, G. C. A1 Lantier, I. A1 Cawthraw, S. A1 Berthon, P. A1 Moore, S. J. A1 Arnold, M. E. A1 Windl, O. A1 Simmons, M. M. A1 Andréoletti, O. A1 Bellworthy, S. A1 Lantier, F.YR 2009 T1 Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy JF Journal of General Virology, VO 90 IS 10 SP 2569 OP 2574 DO https://doi.org/10.1099/vir.0.012724-0 PB Microbiology Society, SN 1465-2099, AB Sheep with an ARQ/ARQ PRNP genotype at codon positions 136/154/171 are highly susceptible to experimental infection with bovine spongiform encephalopathy (BSE). However, a number of sheep challenged orally or intracerebrally with BSE were clinically asymptomatic and found to survive or were diagnosed as BSE-negative when culled. Sequencing of the full PRNP gene open reading frame of BSE-susceptible and -resistant sheep indicated that, in the majority of Suffolk sheep, resistance was associated with an M112T PRNP variant (TARQ allele). A high proportion (47 of 49; 96 %) of BSE-challenged wild-type (MARQ/MARQ) Suffolk sheep were BSE-infected, whereas none of the 20 sheep with at least one TARQ allele succumbed to BSE. Thirteen TARQ-carrying sheep challenged with BSE are still alive and some have survival periods equivalent to, or greater than, reported incubation periods of BSE in ARR/ARR and VRQ/VRQ sheep., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.012724-0