@article{mbs:/content/journal/jgv/10.1099/vir.0.014266-0, author = "Wright, Debbie E. and Colaco, Susanna and Colaco, Camilo and Stevenson, Philip G.", title = "Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions", journal= "Journal of General Virology", year = "2009", volume = "90", number = "11", pages = "2592-2603", doi = "https://doi.org/10.1099/vir.0.014266-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.014266-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization.", }