RT Journal Article SR Electronic(1) A1 Wright, Debbie E. A1 Colaco, Susanna A1 Colaco, Camilo A1 Stevenson, Philip G.YR 2009 T1 Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions JF Journal of General Virology, VO 90 IS 11 SP 2592 OP 2603 DO https://doi.org/10.1099/vir.0.014266-0 PB Microbiology Society, SN 1465-2099, AB Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.014266-0