1887

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Volume 90, Issue 11

Antibody limits murid herpesvirus-4 replication by IgG Fc receptor-dependent functions Free

Abstract

Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization.

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2009-11-01
2024-04-19
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Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions
J. Gen. Virol. 90, 2592 (2009); https://doi.org/10.1099/vir.0.014266-0
/content/journal/jgv/10.1099/vir.0.014266-0
/content/journal/jgv/10.1099/vir.0.014266-0
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