The genome of cyprinid herpesvirus 3 encodes 40 proteins incorporated in mature virions
Michel, B. and Leroy, B. and Stalin Raj, V. and Lieffrig, F. and Mast, J. and Wattiez, R. and Vanderplasschen, A. F. and Costes, B.,, 91, 452-462 (2010),
doi = https://doi.org/10.1099/vir.0.015198-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Koi herpesvirus, also known as cyprinid herpesvirus 3 (CyHV-3), is the aetiological agent of an emerging and mortal disease in common and koi carp. CyHV-3 virions present the characteristic morphology of other members of the order Herpesvirales, being composed of an envelope, a capsid containing the genome and a tegument. This study identified CyHV-3 structural proteins and the corresponding encoding genes using liquid chromatography tandem mass spectrometry-based proteomic approaches. In addition, exponentially modified protein abundance index analyses were used to estimate the relative abundance of the identified proteins in CyHV-3 virions. These analyses resulted in the identification of 40 structural proteins, which were classified based on bioinformatic analyses as capsid (three), envelope (13), tegument (two) and unclassified (22) structural proteins. Finally, a search for host proteins in purified CyHV-3 virions indicated the potential incorporation of up to 18 distinct cellular proteins. The identification of the proteins incorporated into CyHV-3 virions and determination of the viral genes encoding these proteins are key milestones for further fundamental and applied research on this virus.,
language=,
type=