@article{mbs:/content/journal/jgv/10.1099/vir.0.019489-0, author = "Sharma, Sumit and Nakagomi, Toyoko and Nakagomi, Osamu and Paul, Vinod K. and Bhan, Maharaj K. and Ray, Pratima", title = "Convalescent phase sera from children infected with G12 rotavirus cross-neutralize rotavirus strains belonging to the Wa genogroup", journal= "Journal of General Virology", year = "2010", volume = "91", number = "7", pages = "1794-1799", doi = "https://doi.org/10.1099/vir.0.019489-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.019489-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The emergence of G12 rotaviruses raises questions about the ability of candidate vaccines in providing protection against such emerging genotypes. Therefore, we assessed cross-neutralization against four reference rotavirus strains namely Wa (G1P[8]), DS-1 (G2P[4]), 116E (G9P[11]) and RV024 (G12P[6]) using paired sera from 28 children infected with G1P[8], G2P[4], G9P[6/8] or G12P[6] genotypes. Convalescent sera of G12P[6]-infected children demonstrated heterotypic response against 116E and Wa strains (50 and 33.3 %). In contrast, none of the four G2P[4]-infected children seroconverted against Wa or RV024 rotaviruses. The geometric mean neutralizing antibody titre in convalescent sera of G12P[6]-infected children was eightfold higher against strains belonging to the Wa genogroup (i.e. G1, G9 and G12 rotavirus) than against strains belonging to the DS-1 genogroup (G2 rotavirus). In conclusion, this study demonstrates that neutralization in part may be genogroup specific, and thus a monovalent vaccine based on the Wa genogroup is likely to protect against the G12 rotaviruses.", }