%0 Journal Article %A Sharma, Sumit %A Nakagomi, Toyoko %A Nakagomi, Osamu %A Paul, Vinod K. %A Bhan, Maharaj K. %A Ray, Pratima %T Convalescent phase sera from children infected with G12 rotavirus cross-neutralize rotavirus strains belonging to the Wa genogroup %D 2010 %J Journal of General Virology, %V 91 %N 7 %P 1794-1799 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.019489-0 %I Microbiology Society, %X The emergence of G12 rotaviruses raises questions about the ability of candidate vaccines in providing protection against such emerging genotypes. Therefore, we assessed cross-neutralization against four reference rotavirus strains namely Wa (G1P[8]), DS-1 (G2P[4]), 116E (G9P[11]) and RV024 (G12P[6]) using paired sera from 28 children infected with G1P[8], G2P[4], G9P[6/8] or G12P[6] genotypes. Convalescent sera of G12P[6]-infected children demonstrated heterotypic response against 116E and Wa strains (50 and 33.3 %). In contrast, none of the four G2P[4]-infected children seroconverted against Wa or RV024 rotaviruses. The geometric mean neutralizing antibody titre in convalescent sera of G12P[6]-infected children was eightfold higher against strains belonging to the Wa genogroup (i.e. G1, G9 and G12 rotavirus) than against strains belonging to the DS-1 genogroup (G2 rotavirus). In conclusion, this study demonstrates that neutralization in part may be genogroup specific, and thus a monovalent vaccine based on the Wa genogroup is likely to protect against the G12 rotaviruses. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.019489-0