1887

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Volume 91, Issue 8

Lack of association between the presence and persistence of betapapillomavirus DNA in eyebrow hairs and betapapillomavirus L1 antibodies in serum Free

Abstract

Betapapillomavirus (PV) DNA and seroresponses are highly prevalent in the general population and both are frequently used as infection markers in epidemiological studies to elucidate an association with cutaneous squamous cell carcinoma (SCC). Little is known about the natural history of PV infection and the aspects of infection that drive antibody responses. To investigate the relationship between these markers, this study assessed whether the presence or persistence of PV DNA in eyebrow hairs and L1 antibodies of the same PV type co-occurred more frequently than would be expected by chance in both a cross-sectional assessment and a longitudinal study. PV DNA in plucked eyebrow hairs and L1 antibodies in serum were measured in 416 participants of the Australian community-based Nambour Skin Cancer Study in 1996. Similar data were available for a subset of 148 participants in 2003. Observed co-occurrence of PV DNA and antibodies was compared with expected values based on prevalence. A case-wise concordance index was used to calculate the overall concordance of PV DNA and antibodies of the same type. No significant associations were found between the presence or persistence of PV DNA and antibody responses. The age and sex of the host did not influence the association, and nor did SCC status or a history of sunburns. It was concluded that PV antibody responses in adults are not primarily driven by PV infection as measured in eyebrow hairs. Other factors, such as viral load, may play a more pivotal role in the induction of detectable seroresponses.

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2010-08-01
2024-04-19
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References

  1. Adachi A., Kiyono T., Hayashi Y., Ohashi M., Ishibashi M. 1996; Detection of human papillomavirus (HPV) type 47 DNA in malignant lesions from epidermodysplasia verruciformis by protocols for precise typing of related HPV DNAs. J Clin Microbiol 34:369–375
     [Google Scholar]
  2. Andersson K., Waterboer T., Kirnbauer R., Slupetzky K., Iftner T., De Villiers E. M., Forslund O., Pawlita M., Dillner J. 2008; Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions. Cancer Epidemiol Biomarkers Prev 17:189–195
     [Google Scholar]
  3. Antonsson A., Forslund O., Ekberg H., Sterner G., Hansson B. G. 2000; The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. J Virol 74:11636–11641
     [Google Scholar]
  4. Asgari M. M., Kiviat N. B., Critchlow C. W., Stern J. E., Argenyi Z. B., Raugi G. J., Berg D., Odland P. B., Hawes S. E. other authors 2008; Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. J Invest Dermatol 128:1409–1417
     [Google Scholar]
  5. Boom R., Sol C. J., Salimans M. M., Jansen C. L., Wertheim-van Dillen P. M., van der Noordaa J. 1990; Rapid and simple method for purification of nucleic acids. J Clin Microbiol 28:495–503
     [Google Scholar]
  6. Bouwes Bavinck J. N., Stark S., Petridis A. K., Marugg M. E., Ter Schegget J., Westendorp R. G., Fuchs P. G., Vermeer B. J., Pfister H. 2000; The presence of antibodies against virus-like particles of epidermodysplasia verruciformis-associated human papillomavirus type 8 in patients with actinic keratoses. Br J Dermatol 142:103–109
     [Google Scholar]
  7. Boxman I. L., Berkhout R. J., Mulder L. H., Wolkers M. C., Bouwes Bavinck J. N., Vermeer B. J., Ter Schegget J. 1997; Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers. J Invest Dermatol 108:712–715
     [Google Scholar]
  8. Boxman I. L. A., Russell A., Mulder L. H. C., Bavinck J. N. B., Ter Schegget J., Green A. 2001; Association between epidermodysplasia verruciformis-associated human papillomavirus DNA in plucked eyebrow hair and solar keratoses. J Invest Dermatol 117:1108–1112
     [Google Scholar]
  9. Brink A. A., Lloveras B., Nindl I., Heideman D. A., Kramer D., Pol R., Fuente M. J., Meijer C. J., Snijders P. J. 2005; Development of a general-primer-PCR-reverse-line-blotting system for detection of beta and gamma cutaneous human papillomaviruses. J Clin Microbiol 43:5581–5587
     [Google Scholar]
  10. Casabonne D., Michael K. M., Waterboer T., Pawlita M., Forslund O., Burk R. D., Travis R. C., Key T. J., Newton R. 2007; A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 121:1862–1868
     [Google Scholar]
  11. Casabonne D., Lally A., Mitchell L., Michael K. M., Waterboer T., Pawlita M., Imko-Walczuk B., Wojnarowska F., Proby C. other authors 2009; A case–control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: the role of antibodies against human papillomavirus and other risk factors. Int J Cancer 125:1935–1945
     [Google Scholar]
  12. de Koning M., Quint W., Struijk L., Kleter B., Wanningen P., van Doorn L. J., Weissenborn S. J., Feltkamp M., Ter Schegget J. 2006; Evaluation of a novel highly sensitive, broad-spectrum PCR-reverse hybridization assay for detection and identification of beta-papillomavirus DNA. J Clin Microbiol 44:1792–1800
     [Google Scholar]
  13. de Koning M. N., Weissenborn S. J., Abeni D., Bouwes Bavinck J. N., Euvrard S., Green A. C., Harwood C. A., Naldi L., Neale R. other authors 2009; Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. J Gen Virol 90:1611–1621
     [Google Scholar]
  14. De Villiers E. M., Gunst K. 2009; Characterization of seven novel human papillomavirus types isolated from cutaneous tissue, but also present in mucosal lesions. J Gen Virol 90:1999–2004
     [Google Scholar]
  15. Dillner J. 1999; The serological response to papillomaviruses. Semin Cancer Biol 9:423–430
     [Google Scholar]
  16. Evander M., Edlund K., Gustafsson A., Jonsson M., Karlsson R., Rylander E., Wadell G. 1995; Human papillomavirus infection is transient in young women: a population-based cohort study. J Infect Dis 171:1026–1030
     [Google Scholar]
  17. Favre M., Majewski S., Noszczyk B., Maienfisch F., Pura A., Orth G., Jablonska S. 2000; Antibodies to human papillomavirus type 5 are generated in epidermal repair processes. J Invest Dermatol 114:403–407
     [Google Scholar]
  18. Feltkamp M. C. W., Broer R., di Summa F. M., Struijk L., van der Meijden E., Verlaan B. P. J., Westendorp R. G. J., Ter Schegget J., Spaan W. J. M. other authors 2003; Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer. Cancer Res 63:2695–2700
     [Google Scholar]
  19. Gheit T., Billoud G., de Koning M. N., Gemignani F., Forslund O., Sylla B. S., Vaccarella S., Franceschi S., Landi S. other authors 2007; Development of a sensitive and specific multiplex PCR method combined with DNA microarray primer extension to detect betapapillomavirus types. J Clin Microbiol 45:2537–2544
     [Google Scholar]
  20. Green A., Battistutta D., Hart V., Leslie D., Weedon D. 1996; Skin cancer in a subtropical Australian population: incidence and lack of association with occupation. The Nambour Study Group. Am J Epidemiol 144:1034–1040
     [Google Scholar]
  21. Green A., Williams G., Neale R., Hart V., Leslie D., Parsons P., Marks G. C., Gaffney P., Battistutta D. other authors 1999; Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet 354:723–729
     [Google Scholar]
  22. Hildesheim A., Schiffman M. H., Gravitt P. E., Glass A. G., Greer C. E., Zhang T., Scott D. R., Rush B. B., Lawler P. other authors 1994; Persistence of type-specific human papillomavirus infection among cytologically normal women. J Infect Dis 169:235–240
     [Google Scholar]
  23. Ho G. Y., Bierman R., Beardsley L., Chang C. J., Burk R. D. 1998; Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338:423–428
     [Google Scholar]
  24. Huang J. K., Tai J. J. 2007; Twin concordances test for ascertained trichotomous traits data. Stat Med 26:869–894
     [Google Scholar]
  25. Karagas M. R., Nelson H. H., Sehr P., Waterboer T., Stukel T. A., Andrew A., Green A. C., Bavinck J. N., Perry A. other authors 2006; Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst 98:389–395
     [Google Scholar]
  26. Masini C., Fuchs P. G., Gabrielli F., Stark S., Sera F., Ploner M., Melchi C. F., Primavera G., Pirchio G. other authors 2003; Evidence for the association of human papillomavirus infection and cutaneous squamous cell carcinoma in immunocompetent individuals. Arch Dermatol 139:890–894
     [Google Scholar]
  27. McBride P., Neale R., Pandeya N., Green A. 2007; Sun-related factors, Betapapillomavirus , and actinic keratoses: a prospective study. Arch Dermatol 143:862–868
     [Google Scholar]
  28. Michael K. M., Waterboer T., Sehr P., Rother A., Reidel U., Boeing H., Bravo I. G., Schlehofer J., Gartner B. C. other authors 2008; Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathog 4:e1000091
     [Google Scholar]
  29. Pfister H., Fuchs P. G., Majewski S., Jablonska S., Pniewska I., Malejczyk M. 2003; High prevalence of epidermodysplasia verruciformis-associated human papillomavirus DNA in actinic keratoses of the immunocompetent population. Arch Dermatol Res 295:273–279
     [Google Scholar]
  30. Plasmeijer E. I., Neale R. E., de Koning M. N., Quint W. G., McBride P., Feltkamp M. C., Green A. C. 2009; Persistence of betapapillomavirus infections as a risk factor for actinic keratoses, precursor to cutaneous squamous cell carcinoma. Cancer Res 69:8926–8931
     [Google Scholar]
  31. Plasmeijer E. I., Neale R. E., Buettner P. G., de Koning M. N., Ter Schegget J., Quint W. G., Green A. C., Feltkamp M. C. 2010; Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients. Int J Cancer 126:2614–2621
     [Google Scholar]
  32. Rollison D. E., Pawlita M., Giuliano A. R., Iannacone M. R., Sondak V. K., Messina J. L., Cruse C. W., Fenske N. A., Glass L. F. other authors 2008; Measures of cutaneous human papillomavirus infection in normal tissues as biomarkers of HPV in corresponding nonmelanoma skin cancers. Int J Cancer 123:2337–2342
     [Google Scholar]
  33. Stark S., Petridis A. K., Ghim S. J., Jenson A. B., Bouwes Bavinck J. N., Gross G., Stockfleth E., Fuchs P. G., Pfister H. 1998; Prevalence of antibodies against virus-like particles of epidermodysplasia verruciformis-associated HPV8 in patients at risk of skin cancer. J Invest Dermatol 111:696–701
     [Google Scholar]
  34. Struijk L., Bavinck J. N. B., Wanningen P., van der Meijden E., Westendorp R. G. J., Ter Schegget J., Feltkamp M. C. W. 2003; Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma. J Invest Dermatol 121:1531–1535
     [Google Scholar]
  35. Struijk L., Hall L., van der Meijden E., Wanningen P., Bavinck J. N., Neale R., Green A. C., Ter Schegget J., Feltkamp M. C. 2006; Markers of cutaneous human papillomavirus infection in individuals with tumor-free skin, actinic keratoses, and squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 15:529–535
     [Google Scholar]
  36. Waterboer T., Sehr P., Michael K. M., Franceschi S., Nieland J. D., Joos T. O., Templin M. F., Pawlita M. 2005; Multiplex human papillomavirus serology based on in situ-purified glutathione S -transferase fusion proteins. Clin Chem 51:1845–1853
     [Google Scholar]
  37. Waterboer T., Abeni D., Sampogna F., Rother A., Masini C., Sehr P., Michael K. M., Pawlita M. 2008; Serological association of beta and gamma human papillomaviruses with squamous cell carcinoma of the skin. Br J Dermatol 159:457–459
     [Google Scholar]
  38. Waterboer T., Neale R., Michael K. M., Sehr P., de Koning M. N., Weissenborn S. J., Sampogna F., Abeni D., Green A. C. other authors 2009; Antibody responses to 26 skin human papillomavirus types in the Netherlands. Italy and Australia. J Gen Virol 90:1986–1998
     [Google Scholar]
  39. Weissenborn S. J., Nindl I., Purdie K., Harwood C., Proby C., Breuer J., Majewski S., Pfister H., Wieland U. 2005; Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J Invest Dermatol 125:93–97
     [Google Scholar]
  40. Wideroff L., Schiffman M. H., Nonnenmacher B., Hubbert N., Kirnbauer R., Greer C. E., Lowy D., Lorincz A. T., Manos M. M. other authors 1995; Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case–control study of cervical neoplasia. J Infect Dis 172:1425–1430
     [Google Scholar]
  41. zur Hausen H. 1999; Papillomaviruses in human cancers. Proc Assoc Am Physicians 111:581–587
     [Google Scholar]
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Lack of association between the presence and persistence of betapapillomavirus DNA in eyebrow hairs and betapapillomavirus L1 antibodies in serum
J. Gen. Virol. 91, 2073 (2010); https://doi.org/10.1099/vir.0.019976-0
/content/journal/jgv/10.1099/vir.0.019976-0
/content/journal/jgv/10.1099/vir.0.019976-0
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