1887

Abstract

Vertical transmission of JC virus and BK virus has been investigated by few authors, with conflicting results. We performed a combined serological and genomic study of 19 unselected pregnant women and their newborns. Blood and urine samples were collected during each gestational trimester from the pregnant women. Umbilical cord blood, peripheral blood, urine and nasopharyngeal secretion samples were taken from newborns at delivery and after 1 week and 1 month of life. Polyomavirus DNA was detected by nested PCR. Polyomavirus IgG-, IgM- and IgA-specific antibodies were measured in maternal and newborn serum samples using a virus-like-particle-based ELISA method. BKV and JCV DNA were detected in urine from 4 (21 %) and 5 (26 %) women, respectively. BKV and JCV seroprevalences in the pregnant women were 84 % and 42 %, respectively. Using a rise in the IgG level or the transient appearance of an IgA or IgM response as evidence of infection in the newborn, we detected BKV and JCV infections in four (21 %) and three (16 %) newborns, respectively. Three infants had serological evidence of infection with both BKV and JCV. In two of the four possible BKV-infected newborns, the mothers seroconverted during pregnancy, while another mother was viruric and IgA seropositive. The mother of one of the three possible JCV-infected newborns was viruric and IgA seropositive; another mother was viruric. These results suggest JC virus and BK virus can be transmitted from mother to newborn during pregnancy or soon after birth.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.028571-0
2011-05-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/92/5/1044.html?itemId=/content/journal/jgv/10.1099/vir.0.028571-0&mimeType=html&fmt=ahah

References

  1. Arthur R. R., Shah K. V. 1989; Occurrence and significance of papovaviruses BK and JC in the urine. Prog Med Virol 36:42–61[PubMed]
    [Google Scholar]
  2. Berger J. R., Pall L., Lanska D., Whiteman M. 1998; Progressive multifocal leukoencephalopathy in patients with HIV infection. J Neurovirol 4:59–68 [View Article][PubMed]
    [Google Scholar]
  3. Bialasiewicz S., Whiley D. M., Lambert S. B., Nissen M. D., Sloots T. P. 2009; Detection of BK, JC, WU, or KI polyomaviruses in faecal, urine, blood, cerebrospinal fluid and respiratory samples. J Clin Virol 45:249–254 [View Article][PubMed]
    [Google Scholar]
  4. Bofill-Mas S., Pina S., Girones R. 2000; Documenting the epidemiologic patterns of polyomaviruses in human populations by studying their presence in urban sewage. Appl Environ Microbiol 66:238–245 [View Article][PubMed]
    [Google Scholar]
  5. Boldorini R., Zorini E. O., Viganò P., Nebuloni M., Mena M., Monga G. 2000; Cytologic and biomolecular diagnosis of polyomavirus infection in urine specimens of HIV-positive patients. Acta Cytol 44:205–210[PubMed] [CrossRef]
    [Google Scholar]
  6. Boldorini R., Brustia M., Veggiani C., Barco D., Andorno S., Monga G. 2005; Periodic assessment of urine and serum by cytology and molecular biology as a diagnostic tool for BK virus nephropathy in renal transplant patients. Acta Cytol 49:235–243[PubMed] [CrossRef]
    [Google Scholar]
  7. Boldorini R., Veggiani C., Amoruso E., Allegrini S., Miglio U., Paganotti A., Ribaldone R., Monga G. 2008; Latent human polyomavirus infection in pregnancy: investigation of possible transplacental transmission. Pathology 40:72–77 [View Article][PubMed]
    [Google Scholar]
  8. Borgatti M., Costanzo F., Portolani M., Vullo C., Osti C., Masi M., Barbanti-Brodano G. 1979; Evidence for reactivation of persistent infection during pregnancy and lack of congenital transmission of BK virus, a human papovavirus. Microbiologica 2:173–178
    [Google Scholar]
  9. Brown P., Tsai T., Gajdusek D. C. 1975; Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. Am J Epidemiol 102:331–340[PubMed]
    [Google Scholar]
  10. Coleman D. V., Wolfendale M. R., Daniel R. A., Dhanjal N. K., Gardner S. D., Gibson P. E., Field A. M. 1980; A prospective study of human polyomavirus infection in pregnancy. J Infect Dis 142:1–8[PubMed] [CrossRef]
    [Google Scholar]
  11. Dörries K., Vogel E., Günther S., Czub S. 1994; Infection of human polyomaviruses JC and BK in peripheral blood leukocytes from immunocompetent individuals. Virology 198:59–70 [View Article][PubMed]
    [Google Scholar]
  12. Ferrante P., Caldarelli-Stefano R., Omodeo-Zorini E., Vago L., Boldorini R., Costanzi G. 1995; PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy. J Med Virol 47:219–225 [View Article][PubMed]
    [Google Scholar]
  13. Gardner S. D., Field A. M., Coleman D. V., Hulme B. 1971; New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 297:1253–1257 [View Article][PubMed]
    [Google Scholar]
  14. Gibson P. E., Field A. M., Gardner S. D., Coleman D. V. 1981; Occurrence of IgM antibodies against BK and JC polyomaviruses during pregnancy. J Clin Pathol 34:674–679 [View Article][PubMed]
    [Google Scholar]
  15. Goudsmit J., Wertheim-van Dillen P., van Strien A., van der Noordaa J. 1982; The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol 10:91–99 [View Article][PubMed]
    [Google Scholar]
  16. Hirsch H. H., Snydman D. R. 2005; BK virus: opportunity makes a pathogen. Clin Infect Dis 41:354–360 [View Article][PubMed]
    [Google Scholar]
  17. Jin L., Gibson P. E., Booth J. C., Clewley J. P. 1993; Genomic typing of BK virus in clinical specimens by direct sequencing of polymerase chain reaction products. J Med Virol 41:11–17 [View Article][PubMed]
    [Google Scholar]
  18. Jin L., Pietropaolo V., Booth J. C., Ward K. H., Brown D. W. 1995; Prevalence and distribution of BK virus subtypes in healthy people and immunocompromised patients detected by PCR-restriction enzyme analysis. Clin Diagn Virol 3:285–295 [View Article][PubMed]
    [Google Scholar]
  19. Kalvatchev Z., Slavov S., Shtereva M., Savova S. 2008; Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission. J Clin Virol 43:328–329 [View Article][PubMed]
    [Google Scholar]
  20. Knowles W. A., Pipkin P., Andrews N., Vyse A., Minor P., Brown D. W., Miller E. 2003; Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 71:115–123 [View Article][PubMed]
    [Google Scholar]
  21. Koos L. 1979; The urinary tract in absence of cancer. In Diagnostic Cytology and Histopathologic Bases, 3rd edn. pp. 711–748 Edited by Koos L. Philadelphia: Lippincott JB;
    [Google Scholar]
  22. Kunitake T., Kitamura T., Guo J., Taguchi F., Kawabe K., Yogo Y. 1995; Parent-to-child transmission is relatively common in the spread of the human polyomavirus JC virus. J Clin Microbiol 33:1448–1451[PubMed]
    [Google Scholar]
  23. Markowitz R. B., Eaton B. A., Kubik M. F., Latorra D., McGregor J. A., Dynan W. S. 1991; BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions. J Virol 65:4515–4519[PubMed]
    [Google Scholar]
  24. Nickeleit V., Hirsch H. H., Binet I. F., Gudat F., Prince O., Dalquen P., Thiel G., Mihatsch M. J. 1999; Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol 10:1080–1089[PubMed]
    [Google Scholar]
  25. Padgett B. L., Walker D. L., ZuRhein G. M., Eckroade R. J., Dessel B. H. 1971; Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 297:1257–1260 [View Article][PubMed]
    [Google Scholar]
  26. Patel N., Halvorson S., Sroller V., Arrington A., Wong C., Smith E., Vilchez R., Butel J. 2009; Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters. Virology 386:94–101[PubMed] [CrossRef]
    [Google Scholar]
  27. Pietropaolo V., Di Taranto C., Degener A. M., Jin L., Sinibaldi L., Baiocchini A., Melis M., Orsi N. 1998; Transplacental transmission of human polyomavirus BK. J Med Virol 56:372–376 [View Article][PubMed]
    [Google Scholar]
  28. Possati L., Bartolotta E. 1981; Attempts to isolate BK virus from children affected by various diseases. Acta Virol 25:254–255[PubMed]
    [Google Scholar]
  29. Reese J. M., Reissing M., Daniel R. W., Shah K. V. 1975; Occurrence of BK virus and BK virus-specific antibodies in the urine of patients receiving chemotherapy for malignancy. Infect Immun 11:1375–1381[PubMed]
    [Google Scholar]
  30. Rziha H. J., Bornkamm G. W., zur Hausen H. 1978; BK virus: I. Seroepidemiologic studies and serologic response to viral infection. Med Microbiol Immunol (Berl) 165:73–81 [View Article][PubMed]
    [Google Scholar]
  31. Shah K., Daniel R., Madden D., Stagno S. 1980; Serological investigation of BK papovavirus infection in pregnant women and their offspring. Infect Immun 30:29–35[PubMed]
    [Google Scholar]
  32. Stolt A., Sasnauskas K., Koskela P., Lehtinen M., Dillner J. 2003; Seroepidemiology of the human polyomaviruses. J Gen Virol 84:1499–1504 [View Article][PubMed]
    [Google Scholar]
  33. Sundsfjord A., Johansen T., Flaegstad T., Moens U., Villand P., Subramani S., Traavik T. 1990; At least two types of control regions can be found among naturally occurring BK virus strains. J Virol 64:3864–3871[PubMed]
    [Google Scholar]
  34. Taguchi F., Nagaki D., Saito M., Haruyama C., Iwasaki K. 1975; Transplacental transmission of BK virus in human. Jpn J Microbiol 19:395–398[PubMed] [CrossRef]
    [Google Scholar]
  35. Vanchiere J. A., Nicome R. K., Greer J. M., Demmler G. J., Butel J. S. 2005; Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis 192:658–664 [View Article][PubMed]
    [Google Scholar]
  36. Viscidi R. P., Rollison D. E., Viscidi E., Clayman B., Rubalcaba E., Daniel R., Major E. O., Shah K. V. 2003a; Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays. Clin Diagn Lab Immunol 10:278–285[PubMed]
    [Google Scholar]
  37. Viscidi R. P., Ahdieh-Grant L., Schneider M. F., Clayman B., Massad L. S., Anastos K. M., Burk R. D., Minkoff H., Palefsky J. et al. 2003b; Serum immunoglobulin A response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis 188:1834–1844 [View Article][PubMed]
    [Google Scholar]
  38. Walker D. L., Padgett B. L. 1983; The epidemiology of human polyomaviruses. Prog Clin Biol Res 105:99–106[PubMed]
    [Google Scholar]
  39. Zhang S., McNees A. L., Butel J. S. 2005; Quantification of vertical transmission of Murine polyoma virus by real-time quantitative PCR. J Gen Virol 86:2721–2729 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.028571-0
Loading
/content/journal/jgv/10.1099/vir.0.028571-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error