1887

Journal of General Virology header logo

Volume 92, Issue 10

A naturally occurring human adenovirus type 7 variant with a 1743 bp deletion in the E3 cassette Free

Abstract

Human adenovirus type 7 (HAdV-7) is an important cause of acute respiratory disease (ARD). Different genomic variants of HAdV-7 have been described, designated 7a–7l. In a previous study to investigate risk factors for ARD and wheezing, nasopharyngeal samples were collected from 90 ill children seeking medical attention in Ribeirão Preto, São Paulo, Brazil. HAdVs were identified in 31 samples and were characterized by serum neutralization and genome restriction analysis. Eleven HAdVs were identified as being HAdV-7, five of which were classified as being of genome type 7p (Gomen). Six other HAdV-7 isolates gave new restriction profiles with all enzymes used and were classified as being a new genomic variant, 7m. These isolates were further characterized by sequencing. The hexon and fiber genes of the 7m variant were nearly identical to the prototype, 7p. However, nucleotide sequences from the E3 cassette revealed a 1743 bp deletion affecting the 16.1K, 19K, 20.1K and 20.5K ORFs.

  • Received:
  • Accepted:
  • Published Online:
© 2011 SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.029181-0
2011-10-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/92/10/2399.html?itemId=/content/journal/jgv/10.1099/vir.0.029181-0&mimeType=html&fmt=ahah

References

  1. Azar R., Varsano N., Mileguir F., Mendelson E. 1998; Molecular epidemiology of adenovirus type 7 in Israel: identification of two new genome types, Ad7k and Ad7d2. J Med Virol 54:291–299 [View Article][PubMed]
     [Google Scholar]
  2. Bailey A. S., Richmond S. J. 1986; Genetic heterogeneity of recent isolates of adenovirus types 3, 4, and 7. J Clin Microbiol 24:30–35[PubMed]
     [Google Scholar]
  3. Benedict C. A., Norris P. S., Prigozy T. I., Bodmer J. L., Mahr J. A., Garnett C. T., Martinon F., Tschopp J., Gooding L. R., Ware C. F. 2001; Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2. J Biol Chem 276:3270–3278 [View Article][PubMed]
     [Google Scholar]
  4. Benkö M., Harrach B. 2003; Molecular evolution of adenoviruses. Curr Top Microbiol Immunol 272:3–35[PubMed]
     [Google Scholar]
  5. Berge T. O., England B., Mauris C., Shuey H. E., Lennette E. H. 1955; Etiology of acute respiratory disease among service personnel at Fort Ord, California. Am J Hyg 62:283–294[PubMed]
     [Google Scholar]
  6. Burgert H. G., Blusch J. H. 2000; Immunomodulatory functions encoded by the E3 transcription unit of adenoviruses. Virus Genes 21:13–25 [View Article][PubMed]
     [Google Scholar]
  7. Câmara A. A., Silva J. M., Ferriani V. P., Tobias K. R., Macedo I. S., Padovani M. A., Harsi C. M., Cardoso M. R., Chapman M. D. et al.& other authors ( 2004; Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization. J Allergy Clin Immunol 113:551–557 [View Article][PubMed]
     [Google Scholar]
  8. Choi E. H., Lee H. J., Kim S. J., Eun B. W., Kim N. H., Lee J. A., Lee J. H., Song E. K., Kim S. H. 2006; Ten-year analysis of adenovirus type 7 molecular epidemiology in Korea, 1995–2004: implication of fiber diversity. J Clin Virol 35:388–393 [View Article][PubMed]
     [Google Scholar]
  9. Erdman D. D., Xu W., Gerber S. I., Gray G. C., Schnurr D., Kajon A. E., Anderson L. J. 2002; Molecular epidemiology of adenovirus type 7 in the United States, 1966-2000. Emerg Infect Dis 8:269–277 [View Article][PubMed]
     [Google Scholar]
  10. Ginsberg H. S., Lundholm-Beauchamp U., Horswood R. L., Pernis B., Wold W. S. M., Chanock R. M., Prince G. A. 1989; Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc Natl Acad Sci U S A 86:3823–3827 [View Article][PubMed]
     [Google Scholar]
  11. Ginsberg H. S., Moldawer L. L., Sehgal P. B., Redington M., Kilian P. L., Chanock R. M., Prince G. A. 1991; A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc Natl Acad Sci U S A 88:1651–1655 [View Article][PubMed]
     [Google Scholar]
  12. Gomes S. A., Candeias J. A. N., Monteiro S. P., Pereira H. G., Niel C. 1989; New genome types of adenovirus types 1, 3, and 5 isolated from stools of children in Brazil. J Clin Microbiol 27:1022–1026[PubMed]
     [Google Scholar]
  13. Gray G. C., McCarthy T., Lebeck M. G., Schnurr D. P., Russell K. L., Kajon A. E., Landry M. L., Leland D. S., Storch G. A. et al.& other authors ( 2007; Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004–2006. Clin Infect Dis 45:1120–1131 [View Article][PubMed]
     [Google Scholar]
  14. Hársi C. M., Rolim D. P., Gomes S. A., Gilio A. E., Stewien K. E., Baldacci E. R., Candeias J. A. N. 1995; Adenovirus genome types isolated from stools of children with gastroenteritis in São Paulo, Brazil. J Med Virol 45:127–134 [View Article][PubMed]
     [Google Scholar]
  15. Hawkins L. K., Wold W. S. M. 1995; The E3-20.5K membrane protein of subgroup B human adenoviruses contains O-linked and complex N-linked oligosaccharides. Virology 210:335–344 [View Article][PubMed]
     [Google Scholar]
  16. Hawkins L. K., Wilson-Rawls J., Wold W. S. 1995; Region E3 of subgroup B human adenoviruses encodes a 16-kilodalton membrane protein that may be a distant analog of the E3-6.7K protein of subgroup C adenoviruses. J Virol 69:4292–4298[PubMed]
     [Google Scholar]
  17. Hofmann K., Stoffel W. 1993; TMbase – a database of membrane spanning proteins segments. Biol Chem 374:166
     [Google Scholar]
  18. Horton P., Nakai K. 1997; Better prediction of protein cellular localization sites with the k nearest neighbors classifier. Proc Int Conf Intell Syst Mol Biol 5:147–152[PubMed]
     [Google Scholar]
  19. Horwitz M. S. 2001; Adenovirus immunoregulatory genes and their cellular targets. Virology 279:1–8 [View Article][PubMed]
     [Google Scholar]
  20. Horwitz M. S. 2004; Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J Gene Med 6:Suppl. 1S172–S183 [View Article][PubMed]
     [Google Scholar]
  21. Jones M. S. II, Harrach B., Ganac R. D., Gozum M. M., Dela Cruz W. P., Riedel B., Pan C., Delwart E. L., Schnurr D. P. 2007; New adenovirus species found in a patient presenting with gastroenteritis. J Virol 81:5978–5984 [View Article][PubMed]
     [Google Scholar]
  22. Kajon A. E., Erdman D. D. 2007; Assessment of genetic variability among subspecies b1 human adenoviruses for molecular epidemiology studies. Methods Mol Med 131:335–355 [View Article][PubMed]
     [Google Scholar]
  23. Kajon A. E., Murtagh P., Garcia Franco S., Freire M. C., Weissenbacher M. C., Zorzópulos J. 1990; A new genome type of adenovirus 3 associated with severe lower acute respiratory infection in children. J Med Virol 30:73–76 [View Article][PubMed]
     [Google Scholar]
  24. Kajon A. E., Mistchenko A. S., Videla C., Hortal M., Wadell G., Avendaño L. F. 1996; Molecular epidemiology of adenovirus acute lower respiratory infections of children in the south cone of South America (1991–1994). J Med Virol 48:151–156 [View Article][PubMed]
     [Google Scholar]
  25. Kajon A. E., Portes S. A. R., de Mello W. A., Nascimento J. P., Siqueira M. M. 1999; Genome type analysis of Brazilian adenovirus strains of serotypes 1, 2, 3, 5, and 7 collected between 1976 and 1995. J Med Virol 58:408–412 [View Article][PubMed]
     [Google Scholar]
  26. Kajon A. E., Xu W., Erdman D. D. 2005; Sequence polymorphism in the E3 7.7K ORF of subspecies B1 human adenoviruses. Virus Res 107:11–19 [View Article][PubMed]
     [Google Scholar]
  27. Kim M. R., Lee H. R., Lee G. M. 2000; Epidemiology of acute viral respiratory tract infections in Korean children. J Infect 41:152–158 [View Article][PubMed]
     [Google Scholar]
  28. Lichtenstein D. L., Doronin K., Toth K., Kuppuswamy M., Wold W. S., Tollefson A. E. 2004; Adenovirus E3-6.7K protein is required in conjunction with the E3–RID protein complex for the internalization and degradation of TRAIL receptor 2. J Virol 78:12297–12307 [View Article][PubMed]
     [Google Scholar]
  29. Lu X., Erdman D. D. 2006; Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene. Arch Virol 151:1587–1602 [View Article][PubMed]
     [Google Scholar]
  30. McSharry B. P., Burgert H. G., Owen D. P., Stanton R. J., Prod’homme V., Sester M., Koebernick K., Groh V., Spies T. et al.& other authors ( 2008; Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. J Virol 82:4585–4594 [View Article][PubMed]
     [Google Scholar]
  31. Metzgar D., Osuna M., Yingst S., Rakha M., Earhart K., Elyan D., Esmat H., Saad M. D., Kajon A. E. et al.& other authors ( 2005; PCR analysis of Egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. J Clin Microbiol 43:5743–5752 [View Article][PubMed]
     [Google Scholar]
  32. Metzgar D., Osuna M., Kajon A. E., Hawksworth A. W., Irvine M. I., Russell K. L. 2007; Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. J Infect Dis 196:1465–1473 [View Article][PubMed]
     [Google Scholar]
  33. Mistchenko A. S., Robaldo J. F., Rosman F. C., Koch E. R., Kajon A. E. 1998; Fatal adenovirus infection associated with new genome type. J Med Virol 54:233–236 [View Article][PubMed]
     [Google Scholar]
  34. Moraes M. T., Leite J. P., Siqueira M. M., Portes S. A., Krawczuk M. M., Nascimento J. P. 1997; Genomic characterization of adenovirus serotype 7 isolated in Brazil from acute respiratory disease patients during the period from 1980 to 1991. Rev Inst Med Trop Sao Paulo 39:185–189 [View Article][PubMed]
     [Google Scholar]
  35. Moura P. O., Roberto A. F., Hein N., Baldacci E., Vieira S. E., Ejzenberg B., Perrini P., Stewien K. E., Durigon E. L. et al.& other authors ( 2007a; Molecular epidemiology of human adenovirus isolated from children hospitalized with acute respiratory infection in São Paulo, Brazil. J Med Virol 79:174–181 [View Article][PubMed]
     [Google Scholar]
  36. Moura F. E., Mesquita J. R., Portes S. A., Ramos E. A., Siqueira M. M. 2007b; Antigenic and genomic characterization of adenovirus associated to respiratory infections in children living in Northeast Brazil. Mem Inst Oswaldo Cruz 102:937–941 [View Article][PubMed]
     [Google Scholar]
  37. Noda M., Yoshida T., Sakaguchi T., Ikeda Y., Yamaoka K., Ogino T. 2002; Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the 1995 nationwide outbreak in Japan. J Clin Microbiol 40:140–145 [View Article][PubMed]
     [Google Scholar]
  38. Prince G. A., Porter D. D., Jenson A. B., Horswood R. L., Chanock R. M., Ginsberg H. S. 1993; Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J Virol 67:101–111[PubMed]
     [Google Scholar]
  39. Su X., Tian X., Zhang Q., Li H., Li X., Sheng H., Wang Y., Wu H., Zhou R. 2011; Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China. Virol J 8:91 [View Article][PubMed]
     [Google Scholar]
  40. Tanaka K., Itoh N., Saitoh-Inagawa W., Uchio E., Takeuchi S., Aoki K., Soriano E., Nishi M., Júnior R. B. et al.& other authors ( 2000; Genetic characterization of adenovirus strains isolated from patients with acute conjunctivitis in the city of São Paulo, Brazil. J Med Virol 61:143–149 [View Article][PubMed]
     [Google Scholar]
  41. Wadell G., Varsanyi T. M. 1978; Demonstration of three different subtypes of adenovirus type 7 by DNA restriction site mapping. Infect Immun 21:238–246[PubMed]
     [Google Scholar]
  42. Wadell G., Hammarskjöld M. L., Winberg G., Varsanyi T. M., Sundell G. 1980; Genetic variability of adenoviruses. Ann N Y Acad Sci 354:16–42 [View Article][PubMed]
     [Google Scholar]
  43. Wadell G., Cooney M. K., da Costa Linhares A., de Silva L., Kennett M. L., Kono R., Gui-Fang R., Lindman K., Nascimento J. P. et al.& other authors ( 1985; Molecular epidemiology of adenoviruses: global distribution of adenovirus 7 genome types. J Clin Microbiol 21:403–408[PubMed]
     [Google Scholar]
  44. Windheim M., Hilgendorf A., Burgert H. G. 2004; Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways. Curr Top Microbiol Immunol 273:29–85[PubMed]
     [Google Scholar]
  45. Xu W., McDonough M. C., Erdman D. D. 2000; Species-specific identification of human adenoviruses by a multiplex PCR assay. J Clin Microbiol 38:4114–4120[PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.029181-0
Loading
A naturally occurring human adenovirus type 7 variant with a 1743 bp deletion in the E3 cassette
J. Gen. Virol. 92, 2399 (2011); https://doi.org/10.1099/vir.0.029181-0
/content/journal/jgv/10.1099/vir.0.029181-0
/content/journal/jgv/10.1099/vir.0.029181-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error