Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype
Takahashi, Masaharu and Nishizawa, Tsutomu and Sato, Hiroyuki and Sato, Yukihiro and Jirintai and Nagashima, Shigeo and Okamoto, Hiroaki,, 92, 902-908 (2011),
doi = https://doi.org/10.1099/vir.0.029470-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= While performing a nationwide survey of hepatitis E virus (HEV) infection among 450 wild boars (Sus scrofa leucomystax) that had been captured in Japan between November 2005 and March 2010, we found 16 boars (3.6 %) with ongoing HEV infection: 11 had genotype 3 HEV, four had genotype 4 HEV and the remaining boar was infected with HEV of an unrecognized genotype (designated wbJOY_06). The entire wbJOY_06 genome was sequenced and was found to comprise 7246 nt excluding the poly(A) tail. The wbJOY_06 isolate was highly divergent from known genotype 1–4 HEV isolates derived from humans, swine, wild boars, deer, mongoose and rabbits (n=145) by 22.6–27.7 %, rat HEV isolates (n=2) by 46.0–46.2 %, and avian HEV isolates (n=5) by 52.5–53.1 % over the entire genome. A Simplot analysis revealed no significant recombination between the existing HEV strains of genotypes 1–4. Therefore, we propose that the wbJOY_06 isolate is the first member of a previously unidentified genotype.,
language=,
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