RT Journal Article SR Electronic(1) A1 Ghosh, Souvik A1 Paul, Shyamal Kumar A1 Hossain, Mohammad Akram A1 Alam, Mohammed Mahbub A1 Ahmed, Muzahed Uddin A1 Kobayashi, NobumichiYR 2011 T1 Full genomic analyses of two human G2P[4] rotavirus strains detected in 2005: identification of a caprine-like VP3 gene JF Journal of General Virology, VO 92 IS 5 SP 1222 OP 1227 DO https://doi.org/10.1099/vir.0.029868-0 PB Microbiology Society, SN 1465-2099, AB Although G2P[4] rotaviruses are common causes of infantile diarrhoea, to date only the full genomes of the prototype (strain DS-1) and another old strain, TB-Chen, have been analysed. We report here the full genomic analyses of two Bangladeshi G2P[4] strains, MMC6 and MMC88, detected in 2005. Both the strains exhibited a DS-1-like genotype constellation. Excluding the VP4 and VP7 genes, and except for VP3 of MMC88, the MMC strains were genetically more closely related to the contemporary G2P[4] and several non-G2P[4] human strains than the prototype G2P[4] strain. However, by phylogenetic analyses, the VP2, VP3 (except MMC88), NSP1 and NSP3–5 genes of these strains appeared to share a common origin with those of the prototype strain, whilst their VP1, VP6 and NSP2 genes clustered near a caprine strain. The VP3 gene of MMC88 exhibited maximum relatedness to a local caprine strain, representing the first reported human G2P[4] strain with a gene of animal origin., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.029868-0