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Volume 92, Issue 9

A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization Open Access

Abstract

Glycoprotein B (gB) is a conserved, essential component of gammaherpes virions and so potentially vulnerable to neutralization. However, few good gB-specific neutralizing antibodies have been identified. Here, we show that murid herpesvirus 4 is strongly neutralized by mAbs that recognize an epitope close to one of the gB fusion loops. Antibody binding did not stop gB interacting with its cellular ligands or initiating its fusion-associated conformation change, but did stop gB resolving stably to its post-fusion form, and so blocked membrane fusion to leave virions stranded in late endosomes. The conservation of gB makes this mechanism a possible general route to gammaherpesvirus neutralization.

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  • Accepted:
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© 2011 SGM
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2011-09-01
2024-04-20
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A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization
J. Gen. Virol. 92, 2020 (2011); https://doi.org/10.1099/vir.0.032177-0
/content/journal/jgv/10.1099/vir.0.032177-0
/content/journal/jgv/10.1099/vir.0.032177-0
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