Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains
Ghosh, Souvik and Adachi, Noriaki and Gatheru, Zipporah and Nyangao, James and Yamamoto, Dai and Ishino, Masaho and Urushibara, Noriko and Kobayashi, Nobumichi,, 92, 2201-2208 (2011),
doi = https://doi.org/10.1099/vir.0.033001-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Although G2P[4] rotaviruses are common causes of acute childhood diarrhoea in Africa, to date there are no reports on whole genomic analysis of African G2P[4] strains. In this study, the nearly complete genome sequences of two Kenyan G2P[4] strains, AK26 and D205, detected in 1982 and 1989, respectively, were analysed. Strain D205 exhibited a DS-1-like genotype constellation, whilst strain AK26 appeared to be an intergenogroup reassortant with a Wa-like NSP2 genotype on the DS-1-like genotype constellation. The VP2-4, VP6-7, NSP1, NSP3 and NSP5 genes of strain AK26 and the VP2, VP4, VP7 and NSP1–5 genes of strain D205 were closely related to those of the prototype or other human G2P[4] strains. In contrast, their remaining genes were distantly related, and, except for NSP2 of AK26, appeared to originate from or share a common origin with rotavirus genes of artiodactyl (ruminant and camelid) origin. These observations highlight the complex evolutionary dynamics of African G2P[4] rotaviruses.,
language=,
type=