RT Journal Article SR Electronic(1) A1 Ghosh, Souvik A1 Adachi, Noriaki A1 Gatheru, Zipporah A1 Nyangao, James A1 Yamamoto, Dai A1 Ishino, Masaho A1 Urushibara, Noriko A1 Kobayashi, NobumichiYR 2011 T1 Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains JF Journal of General Virology, VO 92 IS 9 SP 2201 OP 2208 DO https://doi.org/10.1099/vir.0.033001-0 PB Microbiology Society, SN 1465-2099, AB Although G2P[4] rotaviruses are common causes of acute childhood diarrhoea in Africa, to date there are no reports on whole genomic analysis of African G2P[4] strains. In this study, the nearly complete genome sequences of two Kenyan G2P[4] strains, AK26 and D205, detected in 1982 and 1989, respectively, were analysed. Strain D205 exhibited a DS-1-like genotype constellation, whilst strain AK26 appeared to be an intergenogroup reassortant with a Wa-like NSP2 genotype on the DS-1-like genotype constellation. The VP2-4, VP6-7, NSP1, NSP3 and NSP5 genes of strain AK26 and the VP2, VP4, VP7 and NSP1–5 genes of strain D205 were closely related to those of the prototype or other human G2P[4] strains. In contrast, their remaining genes were distantly related, and, except for NSP2 of AK26, appeared to originate from or share a common origin with rotavirus genes of artiodactyl (ruminant and camelid) origin. These observations highlight the complex evolutionary dynamics of African G2P[4] rotaviruses., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.033001-0