1887

Abstract

We report the first identification, genetic characterization and disease association studies of several novel species of canine bocaviruses (CBoV). Evolutionary analysis confirmed that CBoV are genetically distinct from the only other known canine bocavirus, minute virus of canines, with which they share less than 63, 62 and 64 % protein identity in NS, NP and VP genes, respectively. Comparative genetic analysis of 37 VP gene variants found in diseased and healthy animals showed that these novel viruses are genetically highly diverse and are common in canine respiratory infections that have remained undetected until now. Interestingly, we observed that a CBoV genotype with a unique deletion in the VP2 gene was significantly more prevalent in animals with respiratory diseases compared with healthy animals.

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2012-02-01
2024-04-24
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References

  1. Allander T., Tammi M. T., Eriksson M., Bjerkner A., Tiveljung-Lindell A., Andersson B. 2005; Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A 102:12891–12896 [View Article][PubMed]
    [Google Scholar]
  2. Arnold K., Bordoli L., Kopp J., Schwede T. 2006; The swiss-model workspace: a web-based environment for protein structure homology modelling. Bioinformatics 22:195–201 [View Article][PubMed]
    [Google Scholar]
  3. Arthur J. L., Higgins G. D., Davidson G. P., Givney R. C., Ratcliff R. M. 2009; A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog 5:e1000391 [View Article][PubMed]
    [Google Scholar]
  4. Brown K. E. 2010; The expanding range of parvoviruses which infect humans. Rev Med Virol 20:231–244 [View Article][PubMed]
    [Google Scholar]
  5. Carmichael L. E., Schlafer D. H., Hashimoto A. 1991; Pathogenicity of minute virus of canines (MVC) for the canine fetus. Cornell Vet 81:151–171[PubMed]
    [Google Scholar]
  6. Chen A. Y., Cheng F., Lou S., Luo Y., Liu Z., Delwart E., Pintel D., Qiu J. 2010; Characterization of the gene expression profile of human bocavirus. Virology 403:145–154 [View Article][PubMed]
    [Google Scholar]
  7. Cheng W. X., Li J. S., Huang C. P., Yao D. P., Liu N., Cui S. X., Jin Y., Duan Z. J. 2010; Identification and nearly full-length genome characterization of novel porcine bocaviruses. PLoS ONE 5:e13583 [View Article][PubMed]
    [Google Scholar]
  8. Chieochansin T., Chutinimitkul S., Payungporn S., Hiranras T., Samransamruajkit R., Theamboolers A., Poovorawan Y. 2007; Complete coding sequences and phylogenetic analysis of human bocavirus (HBoV). Virus Res 129:54–57 [View Article][PubMed]
    [Google Scholar]
  9. Don M., Söderlund-Venermo M., Hedman K., Ruuskanen O., Allander T., Korppi M. 2011; Don’t forget serum in the diagnosis of human bocavirus infection. J Infect Dis 203:1031–1032, author reply 1032–1033 [View Article][PubMed]
    [Google Scholar]
  10. Emsley P., Cowtan K. 2004; coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60:2126–2132 [View Article][PubMed]
    [Google Scholar]
  11. Fauquet C. M., Mayo M. A., Maniloff J., Desselberger U., Ball L. A. editors 2004 Virus Taxonomy: The Eighth Report of the International Committee on Taxonomy of Viruses Oxford, UK: Academic Press;
    [Google Scholar]
  12. Gurda B. L., Parent K. N., Bladek H., Sinkovits R. S., DiMattia M. A., Rence C., Castro A., McKenna R., Olson N. other authors 2010; Human bocavirus capsid structure: insights into the structural repertoire of the Parvoviridae . J Virol 84:5880–5889 [View Article][PubMed]
    [Google Scholar]
  13. Helps C. R., Lait P., Damhuis A., Björnehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G. other authors 2005; Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries. Vet Rec 156:669–673[PubMed] [CrossRef]
    [Google Scholar]
  14. Hoelzer K., Shackelton L. A., Holmes E. C., Parrish C. R. 2008a; Within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats. J Virol 82:11096–11105 [View Article][PubMed]
    [Google Scholar]
  15. Hoelzer K., Shackelton L. A., Parrish C. R., Holmes E. C. 2008b; Phylogenetic analysis reveals the emergence, evolution and dispersal of carnivore parvoviruses. J Gen Virol 89:2280–2289 [View Article][PubMed]
    [Google Scholar]
  16. Kapoor A., Slikas E., Simmonds P., Chieochansin T., Naeem A., Shaukat S., Alam M. M., Sharif S., Angez M. other authors 2009; A newly identified bocavirus species in human stool. J Infect Dis 199:196–200 [View Article][PubMed]
    [Google Scholar]
  17. Kapoor A., Mehta N., Esper F., Poljsak-Prijatelj M., Quan P. L., Qaisar N., Delwart E., Lipkin W. I. 2010a; Identification and characterization of a new bocavirus species in gorillas. PLoS ONE 5:e11948 [View Article][PubMed]
    [Google Scholar]
  18. Kapoor A., Simmonds P., Slikas E., Li L., Bodhidatta L., Sethabutr O., Triki H., Bahri O., Oderinde B. S. other authors 2010b; Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections. J Infect Dis 201:1633–1643 [View Article][PubMed]
    [Google Scholar]
  19. Kapoor A., Hornig M., Asokan A., Williams B., Henriquez J. A., Lipkin W. I. 2011; Bocavirus episome in infected human tissue contains non-identical termini. PLoS ONE 6:e21362 [View Article][PubMed]
    [Google Scholar]
  20. Laskowski R. A., Rullmannn J. A., MacArthur M. W., Kaptein R., Thornton J. M. 1996; AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8:477–486 [View Article][PubMed]
    [Google Scholar]
  21. Manteufel J., Truyen U. 2008; Animal bocaviruses: a brief review. Intervirology 51:328–334 [View Article][PubMed]
    [Google Scholar]
  22. Martin E. T., Taylor J., Kuypers J., Magaret A., Wald A., Zerr D., Englund J. A. 2009; Detection of bocavirus in saliva of children with and without respiratory illness. J Clin Microbiol 47:4131–4132 [View Article][PubMed]
    [Google Scholar]
  23. Martin E. T., Fairchok M. P., Kuypers J., Magaret A., Zerr D. M., Wald A., Englund J. A. 2010; Frequent and prolonged shedding of bocavirus in young children attending daycare. J Infect Dis 201:1625–1632 [View Article][PubMed]
    [Google Scholar]
  24. Parrish C. R., Kawaoka Y. 2005; The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol 59:553–586 [View Article][PubMed]
    [Google Scholar]
  25. Qiu J., Cheng F., Johnson F. B., Pintel D. 2007; The transcription profile of the bocavirus bovine parvovirus is unlike those of previously characterized parvoviruses. J Virol 81:12080–12085 [View Article][PubMed]
    [Google Scholar]
  26. Shackelton L. A., Holmes E. C. 2006; Phylogenetic evidence for the rapid evolution of human B19 erythrovirus. J Virol 80:3666–3669 [View Article][PubMed]
    [Google Scholar]
  27. Shackelton L. A., Parrish C. R., Truyen U., Holmes E. C. 2005; High rate of viral evolution associated with the emergence of carnivore parvovirus. Proc Natl Acad Sci U S A 102:379–384 [View Article][PubMed]
    [Google Scholar]
  28. Shackelton L. A., Hoelzer K., Parrish C. R., Holmes E. C. 2007; Comparative analysis reveals frequent recombination in the parvoviruses. J Gen Virol 88:3294–3301 [View Article][PubMed]
    [Google Scholar]
  29. Steneroden K. K., Hill A. E., Salman M. D. 2011; A needs-assessment and demographic survey of infection-control and disease awareness in western US animal shelters. Prev Vet Med 98:52–57 [View Article][PubMed]
    [Google Scholar]
  30. Sun Y., Chen A. Y., Cheng F., Guan W., Johnson F. B., Qiu J. 2009; Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses. J Virol 83:3956–3967 [View Article][PubMed]
    [Google Scholar]
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