1887

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Volume 93, Issue 10

Inflammasomes and viruses: cellular defence versus viral offence Open Access

Abstract

Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed ‘inflammasome’. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects.

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© 2012 SGM
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2012-10-01
2024-04-20
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Inflammasomes and viruses: cellular defence versus viral offence
J. Gen. Virol. 93, 2063 (2012); https://doi.org/10.1099/vir.0.042978-0
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/content/journal/jgv/10.1099/vir.0.042978-0
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