@article{mbs:/content/journal/jgv/10.1099/vir.0.042978-0, author = "Gram, Anna M. and Frenkel, Joost and Ressing, Maaike E.", title = "Inflammasomes and viruses: cellular defence versus viral offence", journal= "Journal of General Virology", year = "2012", volume = "93", number = "10", pages = "2063-2075", doi = "https://doi.org/10.1099/vir.0.042978-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.042978-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed ‘inflammasome’. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects.", }