%0 Journal Article %A Gram, Anna M. %A Frenkel, Joost %A Ressing, Maaike E. %T Inflammasomes and viruses: cellular defence versus viral offence %D 2012 %J Journal of General Virology, %V 93 %N 10 %P 2063-2075 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.042978-0 %I Microbiology Society, %X Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed ‘inflammasome’. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.042978-0