Inflammasomes and viruses: cellular defence versus viral offence Gram, Anna M. and Frenkel, Joost and Ressing, Maaike E.,, 93, 2063-2075 (2012), doi = https://doi.org/10.1099/vir.0.042978-0, publicationName = Microbiology Society, issn = 0022-1317, abstract= Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed ‘inflammasome’. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects., language=, type=