RT Journal Article SR Electronic(1) A1 Gram, Anna M. A1 Frenkel, Joost A1 Ressing, Maaike E.YR 2012 T1 Inflammasomes and viruses: cellular defence versus viral offence JF Journal of General Virology, VO 93 IS 10 SP 2063 OP 2075 DO https://doi.org/10.1099/vir.0.042978-0 PB Microbiology Society, SN 1465-2099, AB Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed ‘inflammasome’. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.042978-0