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Volume 93, Issue 11

The fate of influenza A virus after infection of human macrophages and dendritic cells Open Access

Abstract

Airway macrophages (MΦ) and dendritic cells (DC) are important components of the innate host defence. Historically, these immune cells have been considered to play a critical role in controlling the severity of influenza A virus (IAV) infection by limiting virus release, initiating local inflammatory responses and by priming subsequent adaptive immune responses. However, some IAV strains have been reported to replicate productively in human immune cells. Potential amplification and dissemination of IAV from immune cells may therefore be an important virulence determinant. Herein, we will review findings in relation to the fate of IAV following infection of MΦ and DC. Insights regarding the consequences and outcomes of IAV infection of airway MΦ and DC are discussed in order to gain a better understanding of the pathogenesis of influenza virus.

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© 2012 SGM
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2012-11-01
2024-04-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.045021-0
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The fate of influenza A virus after infection of human macrophages and dendritic cells
J. Gen. Virol. 93, 2315 (2012); https://doi.org/10.1099/vir.0.045021-0
/content/journal/jgv/10.1099/vir.0.045021-0
/content/journal/jgv/10.1099/vir.0.045021-0
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