RT Journal Article SR Electronic(1) A1 Roperto, Sante A1 Russo, Valeria A1 Ozkul, Ayhan A1 Sepici-Dincel, Aylin A1 Maiolino, Paola A1 Borzacchiello, Giuseppe A1 Marcus, Ioan A1 Esposito, Iolanda A1 Riccardi, Marita Georgia A1 Roperto, FrancoYR 2013 T1 Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis JF Journal of General Virology, VO 94 IS 2 SP 403 OP 408 DO https://doi.org/10.1099/vir.0.047662-0 PB Microbiology Society, SN 1465-2099, AB Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) β receptor in a double-colour immunofluorescence assay. Our results indicate that the E5–PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.047662-0