Fig mosaic emaravirus p4 protein is involved in cell-to-cell movement
Ishikawa, Kazuya and Maejima, Kensaku and Komatsu, Ken and Netsu, Osamu and Keima, Takuya and Shiraishi, Takuya and Okano, Yukari and Hashimoto, Masayoshi and Yamaji, Yasuyuki and Namba, Shigetou,, 94, 682-686 (2013),
doi = https://doi.org/10.1099/vir.0.047860-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Fig mosaic virus (FMV), a member of the newly formed genus Emaravirus, is a segmented negative-strand RNA virus. Each of the six genomic FMV segments contains a single ORF: that of RNA4 encodes the protein p4. FMV-p4 is presumed to be the movement protein (MP) of the virus; however, direct experimental evidence for this is lacking. We assessed the intercellular distribution of FMV-p4 in plant cells by confocal laser scanning microscopy and we found that FMV-p4 was localized to plasmodesmata and to the plasma membrane accompanied by tubule-like structures. A series of experiments designed to examine the movement functions revealed that FMV-p4 has the capacity to complement viral cell-to-cell movement, prompt GFP diffusion between cells, and spread by itself to neighbouring cells. Altogether, our findings demonstrated that FMV-p4 shares several properties with other viral MPs and plays an important role in cell-to-cell movement.,
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