Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals
Pomier, Carole and Rabaaoui, Samira and Pouliquen, Jean-François and Couppié, Pierre and El Guedj, Myriam and Nacher, Mathieu and Lacoste, Vincent and Wattel, Eric and Kazanji, Mirdad and Mortreux, Franck,, 94, 753-757 (2013),
doi = https://doi.org/10.1099/vir.0.048348-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4+ and CD8+ T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.,
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