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Abstract

Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause persistent or asymptomatic infections, but also acute disease associated with a respiratory syndrome, abortion or lethal haemorrhagic fever. During the past two decades, porcine reproductive and respiratory syndrome virus (PRRSV) and, to a lesser extent, equine arteritis virus (EAV) have attracted attention as veterinary pathogens with significant economic impact. Particularly noteworthy were the ‘porcine high fever disease’ outbreaks in South-East Asia and the emergence of new virulent PRRSV strains in the USA. Recently, the family was expanded with several previously unknown arteriviruses isolated from different African monkey species. At the molecular level, arteriviruses share an intriguing but distant evolutionary relationship with coronaviruses and other members of the order . Nevertheless, several of their characteristics are unique, including virion composition and structure, and the conservation of only a subset of the replicase domains encountered in nidoviruses with larger genomes. During the past 15 years, the advent of reverse genetics systems for EAV and PRRSV has changed and accelerated the structure–function analysis of arterivirus RNA and protein sequences. These systems now also facilitate studies into host immune responses and arterivirus immune evasion and pathogenesis. In this review, we have summarized recent advances in the areas of arterivirus genome expression, RNA and protein functions, virion architecture, virus–host interactions, immunity, and pathogenesis. We have also briefly reviewed the impact of these advances on disease management, the engineering of novel candidate live vaccines and the diagnosis of arterivirus infection.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2013-10-01
2024-03-28
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References

  1. Ammann C. G., Messer R. J., Peterson K. E., Hasenkrug K. J. 2009; Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells. PLoS ONE 4:e6105 [View Article][PubMed]
    [Google Scholar]
  2. Balasuriya U. B., MacLachlan N. J. 2004; The immune response to equine arteritis virus: potential lessons for other arteriviruses. Vet Immunol Immunopathol 102:107–129 [View Article][PubMed]
    [Google Scholar]
  3. Balasuriya U. B., Patton J. F., Rossitto P. V., Timoney P. J., McCollum W. H., MacLachlan N. J. 1997; Neutralization determinants of laboratory strains and field isolates of equine arteritis virus: identification of four neutralization sites in the amino-terminal ectodomain of the G(L) envelope glycoprotein. Virology 232:114–128 [View Article][PubMed]
    [Google Scholar]
  4. Balasuriya U. B., Heidner H. W., Davis N. L., Wagner H. M., Hullinger P. J., Hedges J. F., Williams J. C., Johnston R. E., David Wilson W. other authors 2002; Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis virus induce high level protection against challenge with virulent virus in vaccinated horses. Vaccine 20:1609–1617 [View Article][PubMed]
    [Google Scholar]
  5. Balasuriya U. B. R., Dobbe J. C., Heidner H. W., Smalley V. L., Navarrette A., Snijder E. J., MacLachlan N. J. 2004a; Characterization of the neutralization determinants of equine arteritis virus using recombinant chimeric viruses and site-specific mutagenesis of an infectious cDNA clone. Virology 321:235–246 [View Article][PubMed]
    [Google Scholar]
  6. Balasuriya U. B. R., Hedges J. F., Smalley V. L., Navarrette A., McCollum W. H., Timoney P. J., Snijder E. J., MacLachlan N. J. 2004b; Genetic characterization of equine arteritis virus during persistent infection of stallions. J Gen Virol 85:379–390 [View Article][PubMed]
    [Google Scholar]
  7. Barrette-Ng I. H., Ng K. K. S., Mark B. L., Van Aken D., Cherney M. M., Garen C., Kolodenko Y., Gorbalenya A. E., Snijder E. J., James M. N. 2002; Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem 277:39960–39966 [View Article][PubMed]
    [Google Scholar]
  8. Beerens N., Snijder E. J. 2007; An RNA pseudoknot in the 3′ end of the arterivirus genome has a critical role in regulating viral RNA synthesis. J Virol 81:9426–9436 [View Article][PubMed]
    [Google Scholar]
  9. Beerens N., Selisko B., Ricagno S., Imbert I., van der Zanden L., Snijder E. J., Canard B. 2007; De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase. J Virol 81:8384–8395 [View Article][PubMed]
    [Google Scholar]
  10. Beura L. K., Sarkar S. N., Kwon B., Subramaniam S., Jones C., Pattnaik A. K., Osorio F. A. 2010; Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation. J Virol 84:1574–1584 [View Article][PubMed]
    [Google Scholar]
  11. Beura L. K., Subramaniam S., Vu H. L., Kwon B., Pattnaik A. K., Osorio F. A. 2012; Identification of amino acid residues important for anti-IFN activity of porcine reproductive and respiratory syndrome virus non-structural protein 1. Virology 433:431–439 [View Article][PubMed]
    [Google Scholar]
  12. Bøtner A., Strandbygaard B., Sørensen K. J., Have P., Madsen K. G., Madsen E. S., Alexandersen S. 1997; Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine. Vet Rec 141:497–499 [View Article][PubMed]
    [Google Scholar]
  13. Brown E., Lawson S., Welbon C., Gnanandarajah J., Li J., Murtaugh M. P., Nelson E. A., Molina R. M., Zimmerman J. J. other authors 2009; Antibody response to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic detection and differentiation of PRRSV types I and II. Clin Vaccine Immunol 16:628–635 [View Article][PubMed]
    [Google Scholar]
  14. Butler J. E., Wertz N., Weber P., Lager K. M. 2008; Porcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B cells of all isotypes bearing hydrophobic heavy chain CDR3. J Immunol 180:2347–2356[PubMed] [CrossRef]
    [Google Scholar]
  15. Cafruny W. A. 1989; Lactate dehydrogenase-elevating virus: biology and pathogenesis. Crit Rev Microbiol 17:107–119 [View Article][PubMed]
    [Google Scholar]
  16. Cafruny W. A., Plagemann P. G. W. 1982; Immune response to lactate dehydrogenase-elevating virus: serologically specific rabbit neutralizing antibody to the virus. Infect Immun 37:1007–1012[PubMed]
    [Google Scholar]
  17. Cancel-Tirado S. M., Evans R. B., Yoon K. J. 2004; Monoclonal antibody analysis of porcine reproductive and respiratory syndrome virus epitopes associated with antibody-dependent enhancement and neutralization of virus infection. Vet Immunol Immunopathol 102:249–262 [View Article][PubMed]
    [Google Scholar]
  18. Castillo-Olivares J., de Vries A. A. F., Raamsman M. J. B., Rottier P. J. M., Lakhani K., Westcott D., Tearle J. P., Wood J. L., Mumford J. A. other authors 2001; Evaluation of a prototype sub-unit vaccine against equine arteritis virus comprising the entire ectodomain of the virus large envelope glycoprotein (G(L)): induction of virus-neutralizing antibody and assessment of protection in ponies. J Gen Virol 82:2425–2435[PubMed]
    [Google Scholar]
  19. Castillo-Olivares J., Wieringa R., Bakonyi T., de Vries A. A. F., Davis-Poynter N. J., Rottier P. J. M. 2003; Generation of a candidate live marker vaccine for equine arteritis virus by deletion of the major virus neutralization domain. J Virol 77:8470–8480 [View Article][PubMed]
    [Google Scholar]
  20. Cavanagh D. 1997; Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol 142:629–633[PubMed]
    [Google Scholar]
  21. Chen Z., Rowland R. R. R., Anderson G. W., Palmer G. A., Plagemann P. G. W. 1997; Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection. J Virol 71:2913–2920[PubMed]
    [Google Scholar]
  22. Chen Z., Lawson S., Sun Z., Zhou X., Guan X., Christopher-Hennings J., Nelson E. A., Fang Y. 2010; Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology 398:87–97 [View Article][PubMed]
    [Google Scholar]
  23. Chirnside E. D., Francis P. M., de Vries A. A. F., Sinclair R., Mumford J. A. 1995; Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus. J Virol Methods 54:1–13 [View Article][PubMed]
    [Google Scholar]
  24. Coutelier J. P., Van Broeck J., Wolf S. F. 1995; Interleukin-12 gene expression after viral infection in the mouse. J Virol 69:1955–1958[PubMed]
    [Google Scholar]
  25. Cowley J. A., Dimmock C. M., Spann K. M., Walker P. J. 2000; Gill-associated virus of Penaeus monodon prawns: an invertebrate virus with ORF1a and ORF1b genes related to arteri- and coronaviruses. J Gen Virol 81:1473–1484[PubMed]
    [Google Scholar]
  26. Darwich L., Díaz I., Mateu E. 2010; Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology. Virus Res 154:123–132 [View Article][PubMed]
    [Google Scholar]
  27. Das P. B., Dinh P. X., Ansari I. H., de Lima M., Osorio F. A., Pattnaik A. K. 2010; The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J Virol 84:1731–1740 [View Article][PubMed]
    [Google Scholar]
  28. de Lima M., Ansari I. H., Das P. B., Ku B. J., Martinez-Lobo F. J., Pattnaik A. K., Osorio F. A. 2009; GP3 is a structural component of the PRRSV type II (US) virion. Virology 390:31–36 [View Article][PubMed]
    [Google Scholar]
  29. de Vries A. A. F., Chirnside E. D., Bredenbeek P. J., Gravestein L. A., Horzinek M. C., Spaan W. J. M. 1990; All subgenomic mRNAs of equine arteritis virus contain a common leader sequence. Nucleic Acids Res 18:3241–3247 [View Article][PubMed]
    [Google Scholar]
  30. de Vries A. A. F., Chirnside E. D., Horzinek M. C., Rottier P. J. M. 1992; Structural proteins of equine arteritis virus. J Virol 66:6294–6303[PubMed]
    [Google Scholar]
  31. de Vries A. A. F., Post S. M., Raamsman M. J. B., Horzinek M. C., Rottier P. J. M. 1995; The two major envelope proteins of equine arteritis virus associate into disulfide-linked heterodimers. J Virol 69:4668–4674[PubMed]
    [Google Scholar]
  32. de Wilde A. H., Li Y., van der Meer Y., Vuagniaux G., Lysek R., Fang Y., Snijder E. J., van Hemert M. J. 2013; Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis. J Virol 87:1454–1464 [View Article][PubMed]
    [Google Scholar]
  33. Delputte P. L., Nauwynck H. J. 2004; Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus. J Virol 78:8094–8101 [View Article][PubMed]
    [Google Scholar]
  34. Delputte P. L., Vanderheijden N., Nauwynck H. J., Pensaert M. B. 2002; Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparinlike receptor on porcine alveolar macrophages. J Virol 76:4312–4320 [View Article][PubMed]
    [Google Scholar]
  35. den Boon J. A., Snijder E. J., Chirnside E. D., de Vries A. A. F., Horzinek M. C., Spaan W. J. M. 1991; Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily. J Virol 65:2910–2920[PubMed]
    [Google Scholar]
  36. den Boon J. A., Faaberg K. S., Meulenberg J. J. M., Wassenaar A. L. M., Plagemann P. G. W., Gorbalenya A. E., Snijder E. J. 1995; Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases. J Virol 69:4500–4505[PubMed]
    [Google Scholar]
  37. Dobbe J. C., van der Meer Y., Spaan W. J. M., Snijder E. J. 2001; Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis virus tropism in cell culture. Virology 288:283–294 [View Article][PubMed]
    [Google Scholar]
  38. Dokland T. 2010; The structural biology of PRRSV. Virus Res 154:86–97 [View Article][PubMed]
    [Google Scholar]
  39. Duan X., Nauwynck H. J., Pensaert M. B. 1997; Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Microbiol 56:9–19 [View Article][PubMed]
    [Google Scholar]
  40. Duan X., Nauwynck H. J., Favoreel H. W., Pensaert M. B. 1998; Identification of a putative receptor for porcine reproductive and respiratory syndrome virus on porcine alveolar macrophages. J Virol 72:4520–4523[PubMed]
    [Google Scholar]
  41. Dunowska M., Biggs P. J., Zheng T., Perrott M. R. 2012; Identification of a novel nidovirus associated with a neurological disease of the Australian brushtail possum (Trichosurus vulpecula). Vet Microbiol 156:418–424 [View Article][PubMed]
    [Google Scholar]
  42. Even C., Rowland R. R. R., Plagemann P. G. W. 1995; Cytotoxic T cells are elicited during acute infection of mice with lactate dehydrogenase-elevating virus but disappear during the chronic phase of infection. J Virol 69:5666–5676[PubMed]
    [Google Scholar]
  43. Faaberg K. S., Plagemann P. G. W. 1995; The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography. Virology 212:512–525 [View Article][PubMed]
    [Google Scholar]
  44. Fang Y., Snijder E. J. 2010; The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Res 154:61–76 [View Article][PubMed]
    [Google Scholar]
  45. Fang Y., Christopher-Hennings J., Brown E., Liu H., Chen Z., Lawson S. R., Breen R., Clement T., Gao X. other authors 2008; Development of genetic markers in the non-structural protein 2 region of a US type 1 porcine reproductive and respiratory syndrome virus: implications for future recombinant marker vaccine development. J Gen Virol 89:3086–3096 [View Article][PubMed]
    [Google Scholar]
  46. Fang Y., Treffers E. E., Li Y., Tas A., Sun Z., van der Meer Y., de Ru A. H., van Veelen P. A., Atkins J. F. other authors 2012; Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. Proc Natl Acad Sci U S A 109:E2920–E2928 [View Article][PubMed]
    [Google Scholar]
  47. Firth A. E., Brierley I. 2012; Non-canonical translation in RNA viruses. J Gen Virol 93:1385–1409 [View Article][PubMed]
    [Google Scholar]
  48. Firth A. E., Zevenhoven-Dobbe J. C., Wills N. M., Go Y. Y., Balasuriya U. B., Atkins J. F., Snijder E. J., Posthuma C. C. 2011; Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. J Gen Virol 92:1097–1106 [View Article][PubMed]
    [Google Scholar]
  49. Frias-Staheli N., Giannakopoulos N. V., Kikkert M., Taylor S. L., Bridgen A., Paragas J., Richt J. A., Rowland R. R., Schmaljohn C. S. other authors 2007; Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe 2:404–416 [View Article][PubMed]
    [Google Scholar]
  50. Go Y. Y., Bailey E., Cook D. G., Coleman S. J., Macleod J. N., Chen K. C., Timoney P. J., Balasuriya U. B. 2011a; Genome-wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection. J Virol 85:13174–13184 [View Article][PubMed]
    [Google Scholar]
  51. Go Y. Y., Snijder E. J., Timoney P. J., Balasuriya U. B. 2011b; Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus. Clin Vaccine Immunol 18:268–279 [View Article][PubMed]
    [Google Scholar]
  52. Go Y. Y., Bailey E., Timoney P. J., Shuck K. M., Balasuriya U. B. 2012; Evidence that in vitro susceptibility of CD3+ T lymphocytes to equine arteritis virus infection reflects genetic predisposition of naturally infected stallions to become carriers of the virus. J Virol 86:12407–12410 [View Article][PubMed]
    [Google Scholar]
  53. Godeny E. K., de Vries A. A. F., Wang X. C., Smith S. L., de Groot R. J. 1998; Identification of the leader-body junctions for the viral subgenomic mRNAs and organization of the simian hemorrhagic fever virus genome: evidence for gene duplication during arterivirus evolution. J Virol 72:862–867[PubMed]
    [Google Scholar]
  54. Gorbalenya A. E., Enjuanes L., Ziebuhr J., Snijder E. J. 2006; Nidovirales: evolving the largest RNA virus genome. Virus Res 117:17–37 [View Article][PubMed]
    [Google Scholar]
  55. Gravell M., London W. T., Leon M. E., Palmer A. E., Hamilton R. S. 1986; Elimination of persistent simian hemorrhagic fever (SHF) virus infection in patas monkeys. Proc Soc Exp Biol Med 181:219–225 [View Article][PubMed]
    [Google Scholar]
  56. Han J., Wang Y., Faaberg K. S. 2006; Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res 122:175–182 [View Article][PubMed]
    [Google Scholar]
  57. Han J., Rutherford M. S., Faaberg K. S. 2009; The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities. J Virol 83:9449–9463 [View Article][PubMed]
    [Google Scholar]
  58. Han J., Rutherford M. S., Faaberg K. S. 2010; Proteolytic products of the porcine reproductive and respiratory syndrome virus nsp2 replicase protein. J Virol 84:10102–10112 [View Article][PubMed]
    [Google Scholar]
  59. Han M., Du Y., Song C., Yoo D. 2013; Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the porcine reproductive and respiratory syndrome virus nsp1α subunit. Virus Res 172:54–65 [View Article][PubMed]
    [Google Scholar]
  60. Holyoak G. R., Balasuriya U. B., Broaddus C. C., Timoney P. J. 2008; Equine viral arteritis: current status and prevention. Theriogenology 70:403–414 [View Article][PubMed]
    [Google Scholar]
  61. Huang Y. W., Meng X. J. 2010; Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV). Virus Res 154:141–149 [View Article][PubMed]
    [Google Scholar]
  62. Hwang Y.-K., Brinton M. A. 1998; A 68-nucleotide sequence within the 3′ noncoding region of simian hemorrhagic fever virus negative-strand RNA binds to four MA104 cell proteins. J Virol 72:4341–4351[PubMed]
    [Google Scholar]
  63. Ivanov K. A., Hertzig T., Rozanov M., Bayer S., Thiel V., Gorbalenya A. E., Ziebuhr J. 2004; Major genetic marker of nidoviruses encodes a replicative endoribonuclease. Proc Natl Acad Sci U S A 101:12694–12699 [View Article][PubMed]
    [Google Scholar]
  64. Johnson C. R., Yu W., Murtaugh M. P. 2007; Cross-reactive antibody responses to nsp1 and nsp2 of Porcine reproductive and respiratory syndrome virus . J Gen Virol 88:1184–1195 [View Article][PubMed]
    [Google Scholar]
  65. Johnson C. R., Griggs T. F., Gnanandarajah J., Murtaugh M. P. 2011; Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J Gen Virol 92:1107–1116 [View Article][PubMed]
    [Google Scholar]
  66. Kimman T. G., Cornelissen L. A., Moormann R. J. M., Rebel J. M., Stockhofe-Zurwieden N. 2009; Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 27:3704–3718 [View Article][PubMed]
    [Google Scholar]
  67. Knoops K., Bárcena M., Limpens R. W. A. L., Koster A. J., Mommaas A. M., Snijder E. J. 2012; Ultrastructural characterization of arterivirus replication structures: reshaping the endoplasmic reticulum to accommodate viral RNA synthesis. J Virol 86:2474–2487 [View Article][PubMed]
    [Google Scholar]
  68. Kreutz L. C., Ackermann M. R. 1996; Porcine reproductive and respiratory syndrome virus enters cells through a low pH-dependent endocytic pathway. Virus Res 42:137–147 [View Article][PubMed]
    [Google Scholar]
  69. Kroese M. V., Zevenhoven-Dobbe J. C., Bos-de Ruijter J. N., Peeters B. P., Meulenberg J. J., Cornelissen L. A., Snijder E. J. 2008; The nsp1α and nsp1β papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis. J Gen Virol 89:494–499 [View Article][PubMed]
    [Google Scholar]
  70. Kwon B., Ansari I. H., Pattnaik A. K., Osorio F. A. 2008; Identification of virulence determinants of porcine reproductive and respiratory syndrome virus through construction of chimeric clones. Virology 380:371–378 [View Article][PubMed]
    [Google Scholar]
  71. Langenhorst R. J., Lawson S., Kittawornrat A., Zimmerman J. J., Sun Z., Li Y., Christopher-Hennings J., Nelson E. A., Fang Y. 2012; Development of a fluorescent microsphere immunoassay for detection of antibodies against porcine reproductive and respiratory syndrome virus using oral fluid samples as an alternative to serum-based assays. Clin Vaccine Immunol 19:180–189 [View Article][PubMed]
    [Google Scholar]
  72. Lauck M., Sibley S. D., Hyeroba D., Tumukunde A., Weny G., Chapman C. A., Ting N., Switzer W. M., Kuhn J. H. other authors 2013; Exceptional simian hemorrhagic fever virus diversity in a wild African primate community. J Virol 87:688–691 [View Article][PubMed]
    [Google Scholar]
  73. Lee S. M., Schommer S. K., Kleiboeker S. B. 2004; Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes. Vet Immunol Immunopathol 102:217–231 [View Article][PubMed]
    [Google Scholar]
  74. Lee C., Yoo D. 2006; The small envelope protein of porcine reproductive and respiratory syndrome virus possesses ion channel protein-like properties. Virology 355:30–43 [View Article][PubMed]
    [Google Scholar]
  75. Lee C., Hodgins D., Calvert J. G., Welch S. K., Jolie R., Yoo D. 2006; Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication. Virology 346:238–250 [View Article][PubMed]
    [Google Scholar]
  76. Li K., Chen Z., Plagemann P. G. W. 1998; The neutralization epitope of lactate dehydrogenase-elevating virus is located on the short ectodomain of the primary envelope glycoprotein. Virology 242:239–245 [View Article][PubMed]
    [Google Scholar]
  77. Li K., Schuler T., Chen Z., Glass G. E., Childs J. E., Plagemann P. G. 2000; Isolation of lactate dehydrogenase-elevating viruses from wild house mice and their biological and molecular characterization. Virus Res 67:153–162 [View Article][PubMed]
    [Google Scholar]
  78. Li B., Fang L., Xu Z., Liu S., Gao J., Jiang Y., Chen H., Xiao S. 2009; Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis 15:2032–2035 [View Article][PubMed]
    [Google Scholar]
  79. Li Y., Tas A., Snijder E. J., Fang Y. 2012; Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells. J Gen Virol 93:829–839 [View Article][PubMed]
    [Google Scholar]
  80. Li Y., Zhu L., Lawson S. R., Fang Y. 2013; Targeted mutations in a highly conserved motif of the nsp1β protein impair the interferon antagonizing activity of porcine reproductive and respiratory syndrome virus. J Gen Virol 94:1972–1983 [View Article][PubMed]
    [Google Scholar]
  81. Liu Q., Qin Y., Zhou L., Kou Q., Guo X., Ge X., Yang H., Hu H. 2012; Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells. Virology 429:136–147 [View Article][PubMed]
    [Google Scholar]
  82. London W. T. 1977; Epizootiology, transmission and approach to prevention of fatal simian haemorrhagic fever in rhesus monkeys. Nature 268:344–345 [View Article][PubMed]
    [Google Scholar]
  83. Lopez O. J., Osorio F. A. 2004; Role of neutralizing antibodies in PRRSV protective immunity. Vet Immunol Immunopathol 102:155–163 [View Article][PubMed]
    [Google Scholar]
  84. Lu J., Gao F., Wei Z., Liu P., Liu C., Zheng H., Li Y., Lin T., Yuan S. 2011; A 5′-proximal stem-loop structure of 5′ untranslated region of porcine reproductive and respiratory syndrome virus genome is key for virus replication. Virol J 8:172 [View Article][PubMed]
    [Google Scholar]
  85. MacLachlan N. J., Balasuriya U. B., Hedges J. F., Schweidler T. M., McCollum W. H., Timoney P. J., Hullinger P. J., Patton J. F. 1998; Serologic response of horses to the structural proteins of equine arteritis virus. J Vet Diagn Invest 10:229–236 [View Article][PubMed]
    [Google Scholar]
  86. Magnusson P., Hyllseth B., Marusyk H. 1970; Morphological studies on equine arteritis virus. Arch Gesamte Virusforsch 30:105–112 [View Article][PubMed]
    [Google Scholar]
  87. Maines T. R., Young M., Dinh N. N. N., Brinton M. A. 2005; Two cellular proteins that interact with a stem loop in the simian hemorrhagic fever virus 3′(+)NCR RNA. Virus Res 109:109–124 [View Article][PubMed]
    [Google Scholar]
  88. Makarova K. S., Aravind L., Koonin E. V. 2000; A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae . Trends Biochem Sci 25:50–52 [View Article][PubMed]
    [Google Scholar]
  89. Markine-Goriaynoff D., Nguyen T. D., Bigaignon G., Van Snick J., Coutelier J. P. 2001; Distinct requirements for IL-6 in polyclonal and specific Ig production induced by microorganisms. Int Immunol 13:1185–1192 [View Article][PubMed]
    [Google Scholar]
  90. Markine-Goriaynoff D., Hulhoven X., Cambiaso C. L., Monteyne P., Briet T., Gonzalez M. D., Coulie P., Coutelier J. P. 2002; Natural killer cell activation after infection with lactate dehydrogenase-elevating virus. J Gen Virol 83:2709–2716[PubMed]
    [Google Scholar]
  91. Mengeling W. L. 2005; The porcine reproductive and respiratory syndrome quandary. Part II: Vaccines and vaccination strategy. J Swine Health Prod 13:152–156
    [Google Scholar]
  92. Meulenberg J. J. M., van Nieuwstadt A. P., van Essen-Zandbergen A., Langeveld J. P. M. 1997; Posttranslational processing and identification of a neutralization domain of the GP4 protein encoded by ORF4 of Lelystad virus. J Virol 71:6061–6067[PubMed]
    [Google Scholar]
  93. Meulenberg J. J. M., Bos-de Ruijter J. N. A., van de Graaf R., Wensvoort G., Moormann R. J. 1998; Infectious transcripts from cloned genome-length cDNA of porcine reproductive and respiratory syndrome virus. J Virol 72:380–387[PubMed]
    [Google Scholar]
  94. Molenkamp R., Rozier B. C. D., Greve S., Spaan W. J. M., Snijder E. J. 2000a; Isolation and characterization of an arterivirus defective interfering RNA genome. J Virol 74:3156–3165 [View Article][PubMed]
    [Google Scholar]
  95. Molenkamp R., van Tol H., Rozier B. C. D., van der Meer Y., Spaan W. J. M., Snijder E. J. 2000b; The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription. J Gen Virol 81:2491–2496[PubMed]
    [Google Scholar]
  96. Monastyrska I., Ulasli M., Rottier P. J., Guan J. L., Reggiori F., de Haan C. A. 2013; An autophagy-independent role for LC3 in equine arteritis virus replication. Autophagy 9:164–174 [View Article][PubMed]
    [Google Scholar]
  97. Moore B. D., Balasuriya U. B. R., Watson J. L., Bosio C. M., MacKay R. J., MacLachlan N. J. 2003; Virulent and avirulent strains of equine arteritis virus induce different quantities of TNF-alpha and other proinflammatory cytokines in alveolar and blood-derived equine macrophages. Virology 314:662–670 [View Article][PubMed]
    [Google Scholar]
  98. Murtaugh M. P., Xiao Z. G., Zuckermann F. 2002; Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol 15:533–547 [View Article][PubMed]
    [Google Scholar]
  99. Nauwynck H. J., Duan X., Favoreel H. W., Van Oostveldt P., Pensaert M. B. 1999; Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis. J Gen Virol 80:297–305[PubMed]
    [Google Scholar]
  100. Nedialkova D. D., Ulferts R., van den Born E., Lauber C., Gorbalenya A. E., Ziebuhr J., Snijder E. J. 2009; Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease. J Virol 83:5671–5682 [View Article][PubMed]
    [Google Scholar]
  101. Nedialkova D. D., Gorbalenya A. E., Snijder E. J. 2010; Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs. PLoS Pathog 6:e1000772 [View Article][PubMed]
    [Google Scholar]
  102. Nga P. T., Parquet M. C., Lauber C., Parida M., Nabeshima T., Yu F., Thuy N. T., Inoue S., Ito T. other authors 2011; Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes. PLoS Pathog 7:e1002215 [View Article][PubMed]
    [Google Scholar]
  103. Ostrowski M., Galeota J. A., Jar A. M., Platt K. B., Osorio F. A., Lopez O. J. 2002; Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain. J Virol 76:4241–4250 [View Article][PubMed]
    [Google Scholar]
  104. Parida R., Choi I. S., Peterson D. A., Pattnaik A. K., Laegreid W., Zuckermann F. A., Osorio F. A. 2012; Location of T-cell epitopes in nonstructural proteins 9 and 10 of type-II porcine reproductive and respiratory syndrome virus. Virus Res 169:13–21 [View Article][PubMed]
    [Google Scholar]
  105. Pasternak A. O., van den Born E., Spaan W. J. M., Snijder E. J. 2001; Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis. EMBO J 20:7220–7228 [View Article][PubMed]
    [Google Scholar]
  106. Pasternak A. O., van den Born E., Spaan W. J. M., Snijder E. J. 2003; The stability of the duplex between sense and antisense transcription-regulating sequences is a crucial factor in arterivirus subgenomic mRNA synthesis. J Virol 77:1175–1183 [View Article][PubMed]
    [Google Scholar]
  107. Pasternak A. O., Spaan W. J. M., Snijder E. J. 2006; Nidovirus transcription: how to make sense...?. J Gen Virol 87:1403–1421 [View Article][PubMed]
    [Google Scholar]
  108. Patel D., Nan Y., Shen M., Ritthipichai K., Zhu X., Zhang Y. J. 2010; Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J Virol 84:11045–11055 [View Article][PubMed]
    [Google Scholar]
  109. Pedersen K. W., van der Meer Y., Roos N., Snijder E. J. 1999; Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex. J Virol 73:2016–2026[PubMed]
    [Google Scholar]
  110. Plagemann P. G. W. 2001; Complexity of the single linear neutralization epitope of the mouse arterivirus lactate dehydrogenase-elevating virus. Virology 290:11–20 [View Article][PubMed]
    [Google Scholar]
  111. Plagemann P. G. W. 2004; GP5 ectodomain epitope of porcine reproductive and respiratory syndrome virus, strain Lelystad virus. Virus Res 102:225–230 [View Article][PubMed]
    [Google Scholar]
  112. Plagemann P. G. W., Moennig V. 1992; Lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Adv Virus Res 41:99–192 [View Article][PubMed]
    [Google Scholar]
  113. Plagemann P. G. W., Rowland R. R. R., Faaberg K. S. 2002; The primary neutralization epitope of porcine respiratory and reproductive syndrome virus strain VR-2332 is located in the middle of the GP5 ectodomain. Arch Virol 147:2327–2347 [View Article][PubMed]
    [Google Scholar]
  114. Posthuma C. C., Nedialkova D. D., Zevenhoven-Dobbe J. C., Blokhuis J. H., Gorbalenya A. E., Snijder E. J. 2006; Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle. J Virol 80:1653–1661 [View Article][PubMed]
    [Google Scholar]
  115. Prickett J. R., Zimmerman J. J. 2010; The development of oral fluid-based diagnostics and applications in veterinary medicine. Anim Health Res Rev 11:207–216 [View Article][PubMed]
    [Google Scholar]
  116. Rock D. L. 2007; Colloquium on prospects for development of an effective PRRS vaccine. AASV News Archive http://www.aasv.org/news/story.php?id=2527
    [Google Scholar]
  117. Rowland R. R. R., Schneider P., Fang Y., Wootton S., Yoo D., Benfield D. A. 2003; Peptide domains involved in the localization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus. Virology 316:135–145 [View Article][PubMed]
    [Google Scholar]
  118. Sawicki S. G., Sawicki D. L., Siddell S. G. 2007; A contemporary view of coronavirus transcription. J Virol 81:20–29 [View Article][PubMed]
    [Google Scholar]
  119. Schütze H., Ulferts R., Schelle B., Bayer S., Granzow H., Hoffmann B., Mettenleiter T. C., Ziebuhr J. 2006; Characterization of White bream virus reveals a novel genetic cluster of nidoviruses. J Virol 80:11598–11609 [View Article][PubMed]
    [Google Scholar]
  120. Seybert A., van Dinten L. C., Snijder E. J., Ziebuhr J. 2000; Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases. J Virol 74:9586–9593 [View Article][PubMed]
    [Google Scholar]
  121. Shi M., Lam T. T., Hon C. C., Hui R. K., Faaberg K. S., Wennblom T., Murtaugh M. P., Stadejek T., Leung F. C. 2010; Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res 154:7–17 [View Article][PubMed]
    [Google Scholar]
  122. Snijder E. J., Kikkert M. 2013; Arteriviruses. In Fields Virology, 6th edn. pp. 859–879 Edited by Knipe D. M., Howley P. M. Philadelphia, PA: Lippincott Williams & Wilkins;
    [Google Scholar]
  123. Snijder E. J., Meulenberg J. J. M. 1998; The molecular biology of arteriviruses. J Gen Virol 79:961–979[PubMed]
    [Google Scholar]
  124. Snijder E. J., Wassenaar A. L. M., Spaan W. J. M., Gorbalenya A. E. 1995; The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. J Biol Chem 270:16671–16676[PubMed] [CrossRef]
    [Google Scholar]
  125. Snijder E. J., van Tol H., Pedersen K. W., Raamsman M. J. B., de Vries A. A. F. 1999; Identification of a novel structural protein of arteriviruses. J Virol 73:6335–6345[PubMed]
    [Google Scholar]
  126. Snijder E. J., van Tol H., Roos N., Pedersen K. W. 2001; Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex. J Gen Virol 82:985–994[PubMed]
    [Google Scholar]
  127. Snijder E. J., Bredenbeek P. J., Dobbe J. C., Thiel V., Ziebuhr J., Poon L. L. M., Guan Y., Rozanov M., Spaan W. J. M., Gorbalenya A. E. 2003a; Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol 331:991–1004 [View Article][PubMed]
    [Google Scholar]
  128. Snijder E. J., Dobbe J. C., Spaan W. J. M. 2003b; Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity. J Virol 77:97–104 [View Article][PubMed]
    [Google Scholar]
  129. Sola I., Mateos-Gomez P. A., Almazan F., Zuñiga S., Enjuanes L. 2011; RNA-RNA and RNA-protein interactions in coronavirus replication and transcription. RNA Biol 8:237–248 [View Article][PubMed]
    [Google Scholar]
  130. Song C., Krell P., Yoo D. 2010; Nonstructural protein 1α subunit-based inhibition of NF-κB activation and suppression of interferon-β production by porcine reproductive and respiratory syndrome virus. Virology 407:268–280 [View Article][PubMed]
    [Google Scholar]
  131. Spilman M. S., Welbon C., Nelson E., Dokland T. 2009; Cryo-electron tomography of porcine reproductive and respiratory syndrome virus: organization of the nucleocapsid. J Gen Virol 90:527–535 [View Article][PubMed]
    [Google Scholar]
  132. Stadejek T., Stankevicius A., Murtaugh M. P., Oleksiewicz M. B. 2013; Molecular evolution of PRRSV in Europe: current state of play. Vet Microbiol 165:21–28 [View Article][PubMed]
    [Google Scholar]
  133. Storgaard T., Oleksiewicz M. B., Bøtner A. 1999; Examination of the selective pressures on a live PRRS vaccine virus. Arch Virol 144:2389–2401 [View Article][PubMed]
    [Google Scholar]
  134. Sun M. X., Huang L., Wang R., Yu Y. L., Li C., Li P. P., Hu X. C., Hao H. P., Ishag H. A., Mao X. 2012; Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication. Autophagy 8:1434–1447 [View Article][PubMed]
    [Google Scholar]
  135. Sun Y., Xue F., Guo Y., Ma M., Hao N., Zhang X. C., Lou Z., Li X., Rao Z. 2009; Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha. J Virol 83:10931–10940 [View Article][PubMed]
    [Google Scholar]
  136. Sun Z., Chen Z., Lawson S. R., Fang Y. 2010; The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J Virol 84:7832–7846 [View Article][PubMed]
    [Google Scholar]
  137. Sun Y., Han M., Kim C., Calvert J. G., Yoo D. 2012a; Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus. Viruses 4:424–446 [View Article][PubMed]
    [Google Scholar]
  138. Sun Z., Li Y., Ransburgh R., Snijder E. J., Fang Y. 2012b; Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol 86:3839–3850 [View Article][PubMed]
    [Google Scholar]
  139. Tauraso N. M., Shelokov A., Palmer A. E., Allen A. M. 1968; Simian hemorrhagic fever. 3. Isolation and characterization of a viral agent. Am J Trop Med Hyg 17:422–431[PubMed]
    [Google Scholar]
  140. Thaa B., Kabatek A., Zevenhoven-Dobbe J. C., Snijder E. J., Herrmann A., Veit M. 2009; Myristoylation of the arterivirus E protein: the fatty acid modification is not essential for membrane association but contributes significantly to virus infectivity. J Gen Virol 90:2704–2712 [View Article][PubMed]
    [Google Scholar]
  141. Thanawongnuwech R., Halbur P. G., Thacker E. L. 2000; The role of pulmonary intravascular macrophages in porcine reproductive and respiratory syndrome virus infection. Anim Health Res Rev 1:95–102 [View Article][PubMed]
    [Google Scholar]
  142. Tian K., Yu X., Zhao T., Feng Y., Cao Z., Wang C., Hu Y., Chen X., Hu D. other authors 2007; Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE 2:e526 [View Article][PubMed]
    [Google Scholar]
  143. Tian X., Lu G., Gao F., Peng H., Feng Y., Ma G., Bartlam M., Tian K., Yan J. other authors 2009; Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). J Mol Biol 392:977–993 [View Article][PubMed]
    [Google Scholar]
  144. Tian D., Wei Z., Zevenhoven-Dobbe J. C., Liu R., Tong G., Snijder E. J., Yuan S. 2012; Arterivirus minor envelope proteins are a major determinant of viral tropism in cell culture. J Virol 86:3701–3712 [View Article][PubMed]
    [Google Scholar]
  145. Tijms M. A., van Dinten L. C., Gorbalenya A. E., Snijder E. J. 2001; A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus. Proc Natl Acad Sci U S A 98:1889–1894 [View Article][PubMed]
    [Google Scholar]
  146. Tijms M. A., van der Meer Y., Snijder E. J. 2002; Nuclear localization of non-structural protein 1 and nucleocapsid protein of equine arteritis virus. J Gen Virol 83:795–800[PubMed]
    [Google Scholar]
  147. Timoney P. J., McCollum W. H. 1993; Equine viral arteritis. Vet Clin North Am Equine Pract 9:295–309[PubMed]
    [Google Scholar]
  148. van Aken D., Snijder E. J., Gorbalenya A. E. 2006a; Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing. J Virol 80:3428–3437 [View Article][PubMed]
    [Google Scholar]
  149. van Aken D., Zevenhoven-Dobbe J. C., Gorbalenya A. E., Snijder E. J. 2006b; Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7. J Gen Virol 87:3473–3482 [View Article][PubMed]
    [Google Scholar]
  150. Van Breedam W., Delputte P. L., Van Gorp H., Misinzo G., Vanderheijden N., Duan X., Nauwynck H. J. 2010a; Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage. J Gen Virol 91:1659–1667 [View Article][PubMed]
    [Google Scholar]
  151. Van Breedam W., Van Gorp H., Zhang J. Q., Crocker P. R., Delputte P. L., Nauwynck H. J. 2010b; The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog 6:e1000730 [View Article][PubMed]
    [Google Scholar]
  152. van den Born E., Gultyaev A. P., Snijder E. J. 2004; Secondary structure and function of the 5′-proximal region of the equine arteritis virus RNA genome. RNA 10:424–437 [View Article][PubMed]
    [Google Scholar]
  153. van den Born E., Posthuma C. C., Gultyaev A. P., Snijder E. J. 2005; Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region. J Virol 79:6312–6324 [View Article][PubMed]
    [Google Scholar]
  154. van den Broek M. F., Spörri R., Even C., Plagemann P. G. W., Hänseler E., Hengartner H., Zinkernagel R. M. 1997; Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity. J Immunol 159:1585–1588[PubMed]
    [Google Scholar]
  155. van der Meer Y., van Tol H., Locker J. K., Snijder E. J. 1998; ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex. J Virol 72:6689–6698[PubMed]
    [Google Scholar]
  156. van Dinten L. C., den Boon J. A., Wassenaar A. L. M., Spaan W. J. M., Snijder E. J. 1997; An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription. Proc Natl Acad Sci U S A 94:991–996 [View Article][PubMed]
    [Google Scholar]
  157. van Dinten L. C., Rensen S., Gorbalenya A. E., Snijder E. J. 1999; Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication. J Virol 73:2027–2037[PubMed]
    [Google Scholar]
  158. Van Gorp H., Van Breedam W., Delputte P. L., Nauwynck H. J. 2008; Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus. J Gen Virol 89:2943–2953 [View Article][PubMed]
    [Google Scholar]
  159. van Hemert M. J., de Wilde A. H., Gorbalenya A. E., Snijder E. J. 2008; The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor. J Biol Chem 283:16525–16536 [View Article][PubMed]
    [Google Scholar]
  160. van Kasteren P. B., Beugeling C., Ninaber D. K., Frias-Staheli N., van Boheemen S., Garcia-Sastre A., Snijder E. J., Kikkert M. 2012; Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to downregulate innate immunity. J Virol 86:773–785 [View Article][PubMed]
    [Google Scholar]
  161. van Kasteren P. B., Bailey-Elkin B. A., James T. W., Ninaber D. K., Beugeling C., Khajehpour M., Snijder E. J., Mark B. L., Kikkert M. 2013; Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc Natl Acad Sci U S A 110:E838–E847 [View Article][PubMed]
    [Google Scholar]
  162. van Marle G., Dobbe J. C., Gultyaev A. P., Luytjes W., Spaan W. J. M., Snijder E. J. 1999; Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences. Proc Natl Acad Sci U S A 96:12056–12061 [View Article][PubMed]
    [Google Scholar]
  163. Verheije M. H., Olsthoorn R. C. L., Kroese M. V., Rottier P. J. M., Meulenberg J. J. M. 2002a; Kissing interaction between 3′ noncoding and coding sequences is essential for porcine arterivirus RNA replication. J Virol 76:1521–1526 [View Article][PubMed]
    [Google Scholar]
  164. Verheije M. H., Welting T. J. M., Jansen H. T., Rottier P. J. M., Meulenberg J. J. M. 2002b; Chimeric arteriviruses generated by swapping of the M protein ectodomain rule out a role of this domain in viral targeting. Virology 303:364–373 [View Article][PubMed]
    [Google Scholar]
  165. Vu H. L., Kwon B., Yoon K. J., Laegreid W. W., Pattnaik A. K., Osorio F. A. 2011; Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3. J Virol 85:5555–5564 [View Article][PubMed]
    [Google Scholar]
  166. Wang Y., Liang Y., Han J., Burkhart K. M., Vaughn E. M., Roof M. B., Faaberg K. S. 2008; Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence. Virology 371:418–429 [View Article][PubMed]
    [Google Scholar]
  167. Wassenaar A. L. M., Spaan W. J. M., Gorbalenya A. E., Snijder E. J. 1997; Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. J Virol 71:9313–9322[PubMed]
    [Google Scholar]
  168. Welch S. K., Calvert J. G. 2010; A brief review of CD163 and its role in PRRSV infection. Virus Res 154:98–103 [View Article][PubMed]
    [Google Scholar]
  169. Welch S. K., Jolie R., Pearce D. S., Koertje W. D., Fuog E., Shields S. L., Yoo D., Calvert J. G. 2004; Construction and evaluation of genetically engineered replication-defective porcine reproductive and respiratory syndrome virus vaccine candidates. Vet Immunol Immunopathol 102:277–290 [View Article][PubMed]
    [Google Scholar]
  170. Wieringa R., de Vries A. A. F., Raamsman M. J. B., Rottier P. J. M. 2002; Characterization of two new structural glycoproteins, GP(3) and GP(4), of equine arteritis virus. J Virol 76:10829–10840 [View Article][PubMed]
    [Google Scholar]
  171. Wieringa R., De Vries A. A. F., Post S. M., Rottier P. J. M. 2003a; Intra- and intermolecular disulfide bonds of the GP2b glycoprotein of equine arteritis virus: relevance for virus assembly and infectivity. J Virol 77:12996–13004 [View Article][PubMed]
    [Google Scholar]
  172. Wieringa R., de Vries A. A. F., Rottier P. J. M. 2003b; Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP2b, GP3, and GP4) of equine arteritis virus. J Virol 77:6216–6226 [View Article][PubMed]
    [Google Scholar]
  173. Wieringa R., de Vries A. A. F., van der Meulen J., Godeke G. J., Onderwater J. J. M., van Tol H., Koerten H. K., Mommaas A. M., Snijder E. J., Rottier P. J. 2004; Structural protein requirements in equine arteritis virus assembly. J Virol 78:13019–13027 [View Article][PubMed]
    [Google Scholar]
  174. Wissink E. H. J., Kroese M. V., van Wijk H. A. R., Rijsewijk F. A. M., Meulenberg J. J. M., Rottier P. J. M. 2005; Envelope protein requirements for the assembly of infectious virions of porcine reproductive and respiratory syndrome virus. J Virol 79:12495–12506 [View Article][PubMed]
    [Google Scholar]
  175. Wongyanin P., Buranapraditkul S., Yoo D., Thanawongnuwech R., Roth J. A., Suradhat S. 2012; Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg). J Gen Virol 93:1236–1246 [View Article][PubMed]
    [Google Scholar]
  176. Wood O., Tauraso N. M., Liebhaber H. 1970; Electron microscopic study of tissue cultures infected with simian haemorrhagic fever virus. J Gen Virol 7:129–136 [View Article][PubMed]
    [Google Scholar]
  177. Wootton S. K., Rowland R. R. R., Yoo D. 2002; Phosphorylation of the porcine reproductive and respiratory syndrome virus nucleocapsid protein. J Virol 76:10569–10576 [View Article][PubMed]
    [Google Scholar]
  178. Wu W. H., Fang Y., Farwell R., Steffen-Bien M., Rowland R. R., Christopher-Hennings J., Nelson E. A. 2001; A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology 287:183–191 [View Article][PubMed]
    [Google Scholar]
  179. Xue F., Sun Y., Yan L., Zhao C., Chen J., Bartlam M., Li X., Lou Z., Rao Z. 2010; The crystal structure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1beta reveals a novel metal-dependent nuclease. J Virol 84:6461–6471 [View Article][PubMed]
    [Google Scholar]
  180. Yoon K. J., Wu L. L., Zimmerman J. J., Hill H. T., Platt K. B. 1996; Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs. Viral Immunol 9:51–63 [View Article][PubMed]
    [Google Scholar]
  181. Zevenhoven-Dobbe J. C., Greve S., van Tol H., Spaan W. J. M., Snijder E. J. 2004; Rescue of disabled infectious single-cycle (DISC) equine arteritis virus by using complementing cell lines that express minor structural glycoproteins. J Gen Virol 85:3709–3714 [View Article][PubMed]
    [Google Scholar]
  182. Zhang J., Timoney P. J., Shuck K. M., Seoul G., Go Y. Y., Lu Z., Powell D. G., Meade B. J., Balasuriya U. B. 2010; Molecular epidemiology and genetic characterization of equine arteritis virus isolates associated with the 2006–2007 multi-state disease occurrence in the USA. J Gen Virol 91:2286–2301 [View Article][PubMed]
    [Google Scholar]
  183. Ziebuhr J., Snijder E. J., Gorbalenya A. E. 2000; Virus-encoded proteinases and proteolytic processing in the Nidovirales. . J Gen Virol 81:853–879[PubMed]
    [Google Scholar]
  184. Zimmerman J. J., Benfield D. A., Dee S. A., Murtaugh M. P., Stadejek T., Stevenson G. W., Torremorell M. 2012; Porcine reproductive and respiratory syndrome virus (porcine arterivirus). In Disease of Swine, 10th edn. pp. 461–486 Edited by Zimmerman J. J., Karriker L. A., Ramirez A., Schwartz K. J., Stevenson G. W. Chichester: Wiley;
    [Google Scholar]
  185. Zirkel F., Kurth A., Quan P. L., Briese T., Ellerbrok H., Pauli G., Leendertz F. H., Lipkin W. I., Ziebuhr J. other authors 2011; An insect nidovirus emerging from a primary tropical rainforest. MBio 2:e00077-11 [View Article][PubMed]
    [Google Scholar]
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