@article{mbs:/content/journal/jgv/10.1099/vir.0.060640-0, author = "Coleman, Christopher M. and Matthews, Krystal L. and Goicochea, Lindsay and Frieman, Matthew B.", title = "Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus", journal= "Journal of General Virology", year = "2014", volume = "95", number = "2", pages = "408-412", doi = "https://doi.org/10.1099/vir.0.060640-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.060640-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50 % lethality in infected individuals. The development of a small-animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We found that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be due to the low level of mRNA and protein for the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV.", }