RT Journal Article SR Electronic(1) A1 Mohamed, Ghada A1 Vrzalikova, Katerina A1 Cader, Fathima Zumla A1 Vockerodt, Martina A1 Nagy, Eszter A1 Flodr, Patrik A1 Yap, Lee-Fah A1 Diepstra, Arjan A1 Kluin, Philip M. A1 Rosati, Stefano A1 Murray, PaulYR 2014 T1 Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma JF Journal of General Virology, VO 95 IS 9 SP 1861 OP 1869 DO https://doi.org/10.1099/vir.0.066712-0 PB Microbiology Society, SN 1465-2099, AB The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.066712-0