%0 Journal Article %A My, Phan Vu Tra %A Rabaa, Maia A. %A Donato, Celeste %A Cowley, Daniel %A Phat, Voong Vinh %A Dung, Tran Thi Ngoc %A Anh, Pham Hong %A Vinh, Ha %A Bryant, Juliet E. %A Kellam, Paul %A Thwaites, Guy %A Woolhouse, Mark E. J. %A Kirkwood, Carl D. %A Baker, Stephen %T Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam %D 2014 %J Journal of General Virology, %V 95 %N 12 %P 2727-2733 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.068403-0 %I Microbiology Society, %X During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV) – an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26–P[19]–I5–R1–C1–M1–A8–N1–T1–E1–H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1–3 and NSP2–5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.068403-0