Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype
Johansson, E. Susanne and Niklasson, Bo and Tesh, Robert B. and Shafren, Darren R. and Travassos da Rosa, Amelia P. A. and Lindberg, A. Michael,, 84, 837-844 (2003),
doi = https://doi.org/10.1099/vir.0.18792-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Ljungan virus (LV) is a suspected human pathogen recently isolated from bank voles in Sweden. This study describes the genetic characterization of a virus, M1146, which was isolated in 1962 from another vole species (Microtus montanus), trapped in Oregon, USA. Based on antigenic properties, M1146 was postulated previously as a putative member of the family Picornaviridae. The near complete genomic sequence verifies that M1146 is a member of the Picornaviridae, most closely related to LVs isolated in Sweden. The strain M1146 possesses typical LV genomic organization, including a cluster of two 2A homologues. There are significant differences throughout the capsid protein region, while the non-structural region of M1146 is closely related to the Swedish LV genomes. Genetic and phylogenetic analyses show that M1146 represents a new genotype within the distinct LV cluster. Isolation of LV from both Swedish and American voles trapped over a period of 30 years suggests a continuous worldwide presence.,
language=,
type=