1887

Abstract

Serum samples collected periodically from a 40-year-old Japanese woman who had not travelled abroad and who had contracted sporadic acute hepatitis E in 1993 were semi-quantitatively tested by enzyme immunoassay for IgM, IgA and IgG antibodies to hepatitis E virus (HEV). Anti-HEV IgM and IgA antibody levels were the highest (1 : 2400 dilution and 1 : 3400 dilution, respectively) on day 9 after the onset of hepatitis and then decreased rapidly in a parallel manner. Anti-HEV IgG antibody levels were the highest (1 : 17000 dilution) on day 145 and then decreased gradually but remained at high titres (1 : 2200 dilution) even 8·7 years after the onset of hepatitis. An HEV isolate, HE-JA10, recovered from the patient's serum at admission was closely related to a genotype III strain isolated in the United States (US1), with 92·2% identity over the full-length genome, and was most closely related to the JMY-Haw isolate of Japanese origin (95·4% identity).

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18802-0
2003-02-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/2/vir840421.html?itemId=/content/journal/jgv/10.1099/vir.0.18802-0&mimeType=html&fmt=ahah

References

  1. Chau K. H., Dawson G. J., Bile K. M., Magnius L. O., Sjogren M. H., Mushahwar I. K. 1993; Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection. J Med Virol 40:334–338
    [Google Scholar]
  2. Erker J. C., Desai S. M., Schlauder G. G., Dawson G. J., Mushahwar I. K. 1999; A hepatitis E virus variant from the United States: molecular characterization and transmission in cynomolgus macaques. J Gen Virol 80:681–690
    [Google Scholar]
  3. Favorov M. O., Khudyakov Y. E., Mast E. E. 7 other authors 1996; IgM and IgG antibodies to hepatitis E virus (HEV) detected by an enzyme immunoassay based on an HEV-specific artificial recombinant mosaic protein. J Med Virol 50:50–58
    [Google Scholar]
  4. Felsenstein J. 1985; Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783–791
    [Google Scholar]
  5. Garkavenko O., Obriadina A., Meng J., Anderson D. A., Benard H. J., Schroeder B. A., Khudyakov Y. E., Fields H. A., Croxson M. C. 2001; Detection and characterisation of swine hepatitis E virus in New Zealand. J Med Virol 65:525–529
    [Google Scholar]
  6. Harrison T. J. 1999; Hepatitis E virus: an update. Liver 19:171–176
    [Google Scholar]
  7. Hijikata M., Kato N., Ootsuyama Y., Nakagawa M., Ohkoshi S., Shimotohno K. 1991; Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun 175:220–228
    [Google Scholar]
  8. Hsieh S. Y., Meng X. J., Wu Y. H., Liu S. T., Tam A. W., Lin D. Y., Liaw Y. F. 1999; Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J Clin Microbiol 37:3828–3834
    [Google Scholar]
  9. Huang F. F., Haqshenas G., Guenette D. K., Halbur P. G., Schommer S. K., Pierson F. W., Toth T. E., Meng X. J. 2002; Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States. J Clin Microbiol 40:1326–1332
    [Google Scholar]
  10. Kabrane-Lazizi Y., Meng X. J., Purcell R. H., Emerson S. U. 1999; Evidence that the genomic RNA of hepatitis E virus is capped. J Virol 73:8848–8850
    [Google Scholar]
  11. Khuroo M. S., Kamili S., Dar M. Y., Moecklii R., Jameel S. 1993; Hepatitis E and long-term antibody status. Lancet 341:1355
    [Google Scholar]
  12. Krawczynski K., Aggarwal R. 1999; Hepatitis E. In Schiff's Diseases of the Liver . , 8th edn. vol 1 pp  849–860 Edited by Schiff E. R., Sorrell M. F., Maddrey W. C. Philadelphia: Lippincott – Raven;
  13. Kwo P. Y., Schlauder G. G., Carpenter H. A., Murphy P. J., Rosenblatt J. E., Dawson G. J., Mast E. E., Krawczynski K., Balan V. 1997; Acute hepatitis E by a new isolate acquired in the United States. Mayo Clin Proc 72:1133–1136
    [Google Scholar]
  14. Meng X. J., Purcell R. H., Halbur P. G., Lehman J. R., Webb D. M., Tsareva T. S., Haynes J. S., Thacker B. J., Emerson S. U. 1997; A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A 94:9860–9865
    [Google Scholar]
  15. Meng X. J., Halbur P. G., Shapiro M. S., Govindarajan S., Bruna J. D., Mushahwar I. K., Purcell R. H., Emerson S. U. 1998; Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 72:9714–9721
    [Google Scholar]
  16. Meng X. J., Wiseman B., Elvinger F., Guenette D. K., Toth T. E., Engle R. E., Emerson S. U., Purcell R. H. 2002; Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol 40:117–122
    [Google Scholar]
  17. Meyerhans A., Cheynier R., Albert J., Seth M., Kwok S., Sninsky J., Morfeldt-Manson L., Asjo B., Wain-Hobson S. 1989; Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell 58:901–910
    [Google Scholar]
  18. Mizuo H., Suzuki K., Takikawa Y. 8 other authors 2002; Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan. J Clin Microbiol 40:3209–3218
    [Google Scholar]
  19. Okamoto H., Takahashi M., Nishizawa T., Fukai K., Muramatsu U., Yoshikawa A. 2001; Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan. Biochem Biophys Res Commun 289:929–936
    [Google Scholar]
  20. Page R. D. M. 1996; treeview: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12:357–358
    [Google Scholar]
  21. Pina S., Buti M., Cotrina M., Piella J., Girones R. 2000; HEV identified in serum from humans with acute hepatitis and in sewage of animal origin in Spain. J Hepatol 33:826–833
    [Google Scholar]
  22. Purcell R. H., Emerson S. U. 2001a; Hepatitis E virus. In Fields Virology , 4th edn. pp  3051–3061 Edited by Knipe D. M., Howley P. M. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
  23. Purcell R. H., Emerson S. U. 2001b; Animal models of hepatitis A and E. ILAR J 42:161–177
    [Google Scholar]
  24. Reyes G. R., Purdy M. A., Kim J. P., Luk K. C., Young L. M., Fry K. E., Bradley D. W. 1990; Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247:1335–1339
    [Google Scholar]
  25. Saitou N., Nei M. 1987; The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425
    [Google Scholar]
  26. Schlauder G. G., Mushahwar I. K. 2001; Genetic heterogeneity of hepatitis E virus. J Med Virol 65:282–292
    [Google Scholar]
  27. Schlauder G. G., Dawson G. J., Erker J. C., Kwo P. Y., Knigge M. F., Smalley D. L., Rosenblatt J. E., Desai S. M., Mushahwar I. K. 1998; The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States. J Gen Virol 79:447–456
    [Google Scholar]
  28. Schlauder G. G., Desai S. M., Zanetti A. R., Tassopoulos N. C., Mushahwar I. K. 1999; Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV. J Med Virol 57:243–251
    [Google Scholar]
  29. Schlauder G. G., Frider B., Sookoian S., Castano G. C., Mushahwar I. K. 2000; Identification of 2 novel isolates of hepatitis E virus in Argentina. J Infect Dis 182:294–297
    [Google Scholar]
  30. Takahashi K., Iwata K., Watanabe N., Hatahara T., Ohta Y., Baba K., Mishiro S. 2001; Full-genome nucleotide sequence of a hepatitis E virus strain that may be indigenous to Japan. Virology 287:9–12
    [Google Scholar]
  31. Takahashi K., Kang J. H., Ohnishi S., Hino K., Mishiro S. 2002a; Genetic heterogeneity of hepatitis E virus recovered from Japanese patients with acute sporadic hepatitis. J Infect Dis 185:1342–1345
    [Google Scholar]
  32. Takahashi M., Nishizawa T., Yoshikawa A., Sato S., Isoda N., Ido K., Sugano K., Okamoto H. 2002b; Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J Gen Virol 83:1931–1940
    [Google Scholar]
  33. Tam A. W., Smith M. M., Guerra M. E., Huang C. C., Bradley D. W., Fry K. E., Reyes G. R. 1991; Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185:120–131
    [Google Scholar]
  34. Wang Y., Ling R., Erker J. C., Zhang H., Li H., Desai S., Mushahwar I. K., Harrison T. J. 1999; A divergent genotype of hepatitis E virus in Chinese patients with acute hepatitis. J Gen Virol 80:169–177
    [Google Scholar]
  35. Wang Y., Zhang H., Ling R., Li H., Harrison T. J. 2000; The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3. J Gen Virol 81:1675–1686
    [Google Scholar]
  36. Wang Y., Levine D. F., Bendall R. P., Teo C. G., Harrison T. J. 2001; Partial sequence analysis of indigenous hepatitis E virus isolated in the United Kingdom. J Med Virol 65:706–709
    [Google Scholar]
  37. Wang Y., Zhang H., Xia N. 11 other authors 2002; Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol 67:516–521
    [Google Scholar]
  38. Weiner A. J., Brauer M. J., Rosenblatt J. 8 other authors 1991; Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 180:842–848
    [Google Scholar]
  39. Worm H. C., Schlauder G. G., Wurzer H., Mushahwar I. K. 2000; Identification of a novel variant of hepatitis E virus in Austria: sequence, phylogenetic and serological analysis. J Gen Virol 81:2885–2890
    [Google Scholar]
  40. Wu J. C., Chen C. M., Chiang T. Y., Tsai W. H., Jeng W. J., Sheen I. J., Kin C. C., Meng X. J. 2002; Spread of hepatitis E virus among different-aged pigs: two-year survey in Taiwan. J Med Virol 66:488–492
    [Google Scholar]
  41. Zanetti A. R., Schlauder G. G., Romano L., Tanzi E., Fabris P., Dawson G. J., Mushahwar I. K. 1999; Identification of a novel variant of hepatitis E virus in Italy. J Med Virol 57:356–360
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18802-0
Loading
/content/journal/jgv/10.1099/vir.0.18802-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error