1887

Abstract

The murine gammaherpesvirus-68 kills I-A mice despite the presence of virus-specific CD8 cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-A mice and I-A controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4 T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18821-0
2003-02-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/2/vir840337.html?itemId=/content/journal/jgv/10.1099/vir.0.18821-0&mimeType=html&fmt=ahah

References

  1. Annels N. E., Callan M. F., Tan L., Rickinson A. B. 2000; Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response. J Immunol 165:4831–4841
    [Google Scholar]
  2. Appay V., Nixon D. F. Donahoe & 13 other authors 2000; HIV-specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 192:63–75
    [Google Scholar]
  3. Belz G. T., Doherty P. C. 2001; Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection. J Virol 75:4435–4438
    [Google Scholar]
  4. Belz G. T., Stevenson P. G., Castrucci M. R., Altman J. D., Doherty P. C. 2000; Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice. Proc Natl Acad Sci U S A 97:2725–2730
    [Google Scholar]
  5. Boname J. M., Stevenson P. G. 2001; MHC class I ubiquitination by a viral PHD/LAP finger protein. Immunity 15:627–636
    [Google Scholar]
  6. Butz E. A., Bevan M. J. 1998; Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8:167–175
    [Google Scholar]
  7. Cardin R. D., Brooks J. W., Sarawar S. R., Doherty P. C. 1996; Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells. J Exp Med 184:863–871
    [Google Scholar]
  8. Liu H., Andreansky S., Diaz G., Hogg T., Doherty P. C. 2002; Reduced functional capacity of CD8+ T cells expanded by post-exposure vaccination of gamma-herpesvirus-infected CD4-deficient mice. J Immunol 168:3477–3483
    [Google Scholar]
  9. McMichael A. J., Rowland-Jones S. L. 2001; Cellular immune responses to HIV. Nature 410:980–987
    [Google Scholar]
  10. Nash A. A., Dutia B. M., Stewart J. P., Davison A. J. 2001; Natural history of murine gamma-herpesvirus infection. Philos Trans R Soc Lond B Biol Sci 356:569–579
    [Google Scholar]
  11. Pala P., Townsend A. R., Askonas B. A. 1986; Viral recognition by influenza A virus cross-reactive cytotoxic T (Tc) cells: the proportion of Tc cells that recognize nucleoprotein varies between individual mice. Eur J Immunol 16:193–198
    [Google Scholar]
  12. Stevenson P. G., Belz G. T., Altman J. D., Doherty P. C. 1998; Virus-specific CD8+ T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice. Proc Natl Acad Sci U S A 95:15565–15570
    [Google Scholar]
  13. Stevenson P. G., Belz G. T., Altman J. D., Doherty P. C. 1999; Changing patterns of immunodominance in the CD8+ T cell response during acute and persistent murine gammaherpesvirus infection. Eur J Immunol 29:1059–1067
    [Google Scholar]
  14. Virgin H. W. IV, Speck S. H. 1999; Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection. Curr Opin Immunol 11:371–379
    [Google Scholar]
  15. Zajac A. J., Blattman J. N., Murali-Krishna K., Sourdive D. J., Suresh M., Altman J. D., Ahmed R. 1998; Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 188:2205–2213
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18821-0
Loading
/content/journal/jgv/10.1099/vir.0.18821-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error