@article{mbs:/content/journal/jgv/10.1099/vir.0.18821-0, author = "Belz, Gabrielle T. and Liu, Haiyan and Andreansky, Samita and Doherty, Peter C. and Stevenson, Philip G.", title = "Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab−/− mice", journal= "Journal of General Virology", year = "2003", volume = "84", number = "2", pages = "337-341", doi = "https://doi.org/10.1099/vir.0.18821-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18821-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The murine gammaherpesvirus-68 kills I-Ab−/− mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab−/− mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.", }